None of the other pathways tested could lead to all observations about interneuronal dysfunction.
Carlos Perez, Jokubas Ziburkus, Ghanim Ullah 2016, 'Analyzing and Modeling the Dysfunction of Inhibitory Neurons in Alzheimer's Disease',PLOS ONE10.1371/journal.pone.0168800. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, specific cellular mechanisms leading to interneuronal dysfunction are not completely understood.
Carlos Perez, Jokubas Ziburkus, Ghanim Ullah 2016, 'Analyzing and Modeling the Dysfunction of Inhibitory Neurons in Alzheimer's Disease.',PLoS ONEhttp://europepmc.org/articles/PMC5201300?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Neuroblasts proliferate and migrate into the olfactory bulb and differentiate into different interneuronal types.
Giovanna Ponti, Giovanna Ponti, Alice Farinetti, Alice Farinetti, Marilena Marraudino,Marilena Marraudino, GianCarlo Panzica, GianCarlo Panzica, Stefano Gotti, StefanoGotti 2018, 'Sex Steroids and Adult Neurogenesis in the Ventricular-Subventricular Zone', Frontiers in Endocrinologyhttp://journal.frontiersin.org/article/10.3389/fendo.2018.00156/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The interneuronal distribution was assessed by stereological methods applied to every striatal functional territory.
Javier Bernácer, Lucía Prensa, José Manuel Giménez-Amaya 2012, 'Distribution of GABAergic interneurons and dopaminergic cells in the functional territoriesof the human striatum.', PLoS ONEhttp://europepmc.org/articles/PMC3260284?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These results indicate that interneuronal loss and changes in excitability occurredin the hippocampal dentate gyrus.
Bao-Liang Zhang, Yue-Shan Fan, Ji-Wei Wang, Zi-Wei Zhou, Yin-Gang Wu, Meng-Chen Yang,Dong-Dong Sun, Jian-Ning Zhang 2018, 'Cognitive impairment after traumatic brain injury is associated with reduced long-termdepression of excitatory postsynaptic potential in the rat hippocampal dentate gyrus',Neural Regeneration Researchhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=10;spage=1753;epage=1758;aulast=Zhang. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These plasticity-related molecules modulate interneuronal structure and connectivity, particularly of parvalbumin expressingbasket interneurons, both during development and adult life.
Ana Paula Pesarico, Clara Bueno-Fernandez, Ramón Guirado, María Ángeles Gómez-Climent,Yasmina Curto, Hector Carceller, Juan Nacher, Juan Nacher, Juan Nacher 2019, 'Chronic Stress Modulates Interneuronal Plasticity: Effects on PSA-NCAM and PerineuronalNets in Cortical and Extracortical Regions', Frontiers in Cellular Neurosciencehttps://www.frontiersin.org/article/10.3389/fncel.2019.00197/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Fast inhibition in interneuronal networks has been suggested as a general mechanism for the generation of high-frequency oscillations.
Fabiano Baroni, Anthony N Burkitt, David B Grayden 2014, 'Interplay of intrinsic and synaptic conductances in the generation of high-frequencyoscillations in interneuronal networks with irregular spiking.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC4006709?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Immunohistochemistry was used to identify known interneuronal markers for neurotransmission and cell proliferation: parvalbumin, somatostatin subpopulations of interneurons.
Helena M. Minye, Anna-Liisa Fabritius, Jouni Vesa, Leena Peltonen 2016, 'Data on characterizing the gene expression patterns of neuronal ceroid lipofuscinosisgenes: CLN1, CLN2, CLN3, CLN5 and their association to interneuron and neurotransmissionmarkers: Parvalbumin and Somatostatin', Data in Briefhttp://www.sciencedirect.com/science/article/pii/S235234091630395X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We found that the optimal design depends on the number of neurons, interneuronal connectivity, and axon diameter.
Quan Wen, Dmitri B Chklovskii 2005, 'Segregation of the brain into gray and white matter: a design minimizing conductiondelays.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC1323466?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)