This species produced unconjugated and deliquescent asci with hemispheroid or helmet-shaped ascospores.
Fengli Hui, Yongcheng Ren, Liang Chen, Ying Li, Lin Zhang, Qiuhong Niu 2014, 'Molecular phylogenetic analysis reveals the new genus Hemisphaericaspora of the familyDebaryomycetaceae.', PLoS ONEhttp://europepmc.org/articles/PMC4116224?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ang2 conjugation to liposomes markedly improved binding relative to unconjugated liposomes.
Iason Papademetriou, Else Vedula, Joseph Charest, Tyrone Porter 2018, 'Effect of flow on targeting and penetration of angiopep-decorated nanoparticles ina microfluidic model blood-brain barrier', PLOS ONE10.1371/journal.pone.0205158. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These harmful effects indicate the need to develop alternative pharmacological treatment strategies for unconjugated hyperbilirubinemia.
Somayyeh Hashemian, Ashraf Mohammad zadeh, Alireza Ataee nakhaei 2014, 'Efficacy of zinc sulfate in reducing unconjugated hyperbilirubinemia in neonates',Reviews in Clinical Medicinehttp://rcm.mums.ac.ir/pdf_3308_dda654f1be5e0b2ce2c094a2fbf7f20b.html. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Two types are found: conjugated and unconjugated bilirubin jaundice.
Christelle Luce Bobossi Gadia, Alexandre Manirakiza, Gaspard Tekpa, Xavier Konamna,Ulrich Vickos, Emmanuel Nakoune 2017, 'Identification of pathogens for differential diagnosis of fever with jaundice in theCentral African Republic: a retrospective assessment, 2008–2010', BMC Infectious Diseaseshttp://link.springer.com/article/10.1186/s12879-017-2840-8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Inês ePalmela, Leonor eCorreia, Rui eSilva, Rui eSilva, Hiroyuki eSasaki, Kwang SikKim, Dora eBrites, Dora eBrites, Maria A Brito, Maria A Brito 2015, 'Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruptionby unconjugated bilirubin: an in vitro study', Frontiers in Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fnins.2015.00080/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Unconjugated bilirubin plays an important role in cholesterol gallstone formation.
Andrea Cariati, Elisa Piromalli, Nicola Morelli, Giuliano Bottino, Enzo Andorno 2014, 'Indications for Laparoscopic Cholecystectomy or Oral Dissolution Therapy with UrsodeoxycholicAcid in Symptomatic Gallstone Disease', Archives of Clinical and Experimental Surgeryhttp://www.scopemed.org/fulltextpdf.php?mno=47373. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Lab tests' results revealed leukocytosis, macrocytic anemia, severe thrombocytopenia, renal dysfunction, and unconjugated hyperbilirubinemia.
Ramesh Kumar Pandey, Sumit Dahal, Kamal Fadlalla El Jack Fadlalla, Shambhu Bhagat,Bikash Bhattarai 2017, 'Acquired Thrombotic Thrombocytopenic Purpura in a Patient with Pernicious Anemia',Case Reports in Hematologyhttp://dx.doi.org/10.1155/2017/1923607. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
High unconjugated bilirubin could result in acute kidney injury in full-term newborns.
Bangning Cheng, Yulian Jin, Guanghui Liu, Zhiheng Chen, Hongmei Dai, Min Liu 2014, 'Urinary N-Acetyl-beta-D-glucosaminidase as an Early Marker for Acute Kidney Injuryin Full-Term Newborns with Neonatal Hyperbilirubinemia', Disease Markershttp://dx.doi.org/10.1155/2014/315843. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A 56 years male presented with splenomegaly and unconjugated hyperbilirubinemia withnormal hematological indices.
Neetu Rani, Manu Jamwal, Jasbir Kaur, Pankaj Malhotra, Prashant Sharma, Arindam Maitra,Ranvir Singh, Subhash Varma, Reena Das 2017, 'A homozygous KLF1 gene mutation presenting as mild Thalassemia Intermedia unraveledby targeted Next Generation Sequencing', Canadian Journal of Biotechnologyhttps://www.canadianjbiotech.com/CAN_J_BIOTECH/Archives/v1/Special Issue/cjb.2017-a72.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)