The comparison has been made by carrying out iodination reaction in acetic acid and ethanol.
Arvind M. Patil, Sainath B. Zangade, Yeshwant B. Vibhute, Sarala N. Kalyankar 2013, '2-Methoxyethanol: A remarkably efficient and alternative reaction medium for iodinationof reactive aromatics using iodine and iodic acid', Orbital: The Electronic Journal of Chemistryhttp://www.orbital.ufms.br/index.php/Chemistry/article/view/318. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Three examples from the pyrazoles were subjected to the iodination condition shownabove.
Jéssica Kunsminskas, Lucas Pizutti, Cristiano Raminelli 2012, 'Ultrasound-promoted iodination of pyrazoles in aqueous medium', Orbital: The Electronic Journal of Chemistryhttp://www.orbital.ufms.br/index.php/Chemistry/article/view/367. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The rate of the reaction was studied by iodination.
Swati Malhotra, Dipika Kaur Jaspal 2014, 'Enolisation Kinetics of m-Nitro Acetophenone', Bulletin of Chemical Reaction Engineering & Catalysishttp://ejournal.undip.ac.id/index.php/bcrec/article/view/5258. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Monitoring the regioselectivity of the reaction by iodination revealed a 16.6:1.6:1.0 ortho:meta:para ratio.
David R. Armstrong, Liam Balloch, Eva Hevia, Alan R. Kennedy, Robert E. Mulvey, CharlesT. O'Hara, Stuart D. Robertson 2011, 'Meta-metallation of N,N-dimethylaniline: Contrasting direct sodium-mediated zincationwith indirect sodiation-dialkylzinc co-complexation', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.7.144. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Different degrees of iodination were perfomed and the toxicity of the derivatives were analysed by in vivo studies.
P.H. Rocha, R.A. Assis, F.C.F. Lobato, V.N. Cardoso, L.G.D. Heneine 2008, 'Stability and toxicity of Clostridium perfringens type D epsilon prototoxin treatedby iodine Estabilidade e toxicidade da protoxina epsilon de Clostridium perfringenstipo D', Arquivo Brasileiro de Medicina Veterinária e Zootecniahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000400007. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This iodination and peroxidation in a one-pot synthesis produces 1-(tert-butylperoxy)-2-iodoethanes, which are inaccessible through conventional synthetic methods.
Hao Wang, Cui Chen, Weibing Liu, Zhibo Zhu 2017, 'Difunctionalization of alkenes with iodine and tert-butyl hydroperoxide (TBHP) atroom temperature for the synthesis of 1-(tert-butylperoxy)-2-iodoethanes', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.13.200. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Iodination has the same effect.
Christine A. Philip, Anwar Amin, Nabawia A. Moussa 1996, 'Effect of Halide Impregnation on the Structure and Surface Characteristics of Rutile',Adsorption Science & Technologyhttps://doi.org/10.1177/026361749601300405. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)