any of several forms of the same protein, derived either from the same gene or from different genes, each of which is similar in function to the others
Examples of 'isoform' in a sentence
isoform
As a result, this new isoform displays some functional activity.
Alexandre Bolze, Avinash Abhyankar, Audrey V. Grant, Bhavi Patel, Ruchi Yadav, MinjiByun, Daniel Caillez, Jean-Francois Emile, Marçal Pastor-Anglada, Laurent Abel, AnnePuel, Rajgopal Govindarajan, Loic de Pontual, Jean-Laurent Casanova 2012, 'A Mild Form of SLC29A3 Disorder: A Frameshift Deletion Leads to the Paradoxical Translationof an Otherwise Noncoding mRNA Splice Variant', PLoS ONE10.1371/journal.pone.0029708. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Several putative unconfirmed features were also identified, including a possible new isoform.
Sarah E. Boyd, Betina Nair, Sze Woei Ng, Jonathan M. Keith, Jacqueline M. Orian 2012, 'Computational Characterization of 3′ Splice Variants in the GFAP Isoform Family',PLoS ONE10.1371/journal.pone.0033565. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Large scale sequencing techniques have enabled cost effective analysis of gene expression and isoform studies.
Asta Laiho, Noora Kotaja, Attila Gyenesei, Anu Sironen 2013, 'Transcriptome Profiling of the Murine Testis during the First Wave of Spermatogenesis',PLoS ONE10.1371/journal.pone.0061558. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Isoform changes were linked to alterations in transcription as opposed to translation of titin messages.
Wei Guo, Jonathan M. Pleitner, Kurt W. Saupe, Marion L. Greaser 2013, 'Pathophysiological Defects and Transcriptional Profiling in the RBM20-/- Rat Model',PLoS ONE10.1371/journal.pone.0084281. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This isoform was immunologically different from the soluble cytosolic and mitochondrial arginase.
Shilpee Srivastava, B K Ratha 2013, 'Unique hepatic cytosolic arginase evolved independently in ureogenic freshwater air-breathingteleost, Heteropneustes fossilis.', PLoS ONEhttp://europepmc.org/articles/PMC3688715?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the epithelial nitric oxide synthase isoform displayed no significant changes.
Elena Lima-Cabello, Francisco Garcia-Guirado, Rocio Calvo-Medina, Rajaa el Bekay,Lucia Perez-Costillas, Carolina Quintero-Navarro, Lourdes Sanchez-Salido, Yolandade Diego-Otero 2016, 'An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the MouseModel for the Fragile X Syndrome, a Possible Role in Intellectual Disability', Oxidative Medicine and Cellular Longevityhttp://dx.doi.org/10.1155/2016/8548910. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These data elucidate a relationship between transcript isoform expression and translation initiation regulating intercellular communication.
Michael J. Zeitz, Patrick J. Calhoun, Carissa C. James, Thomas Taetzsch, Kijana K.George, Stefanie Robel, Gregorio Valdez, James W. Smyth 2019, 'Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formationduring Stress and Aging', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124719306047. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this model, protective effects of tetrahydrobiopterin are mediated by targeting this isoform.
Benno Cardini, Katrin Watschinger, Martin Hermann, Peter Obrist, Rupert Oberhuber,Gerald Brandacher, Surawee Chuaiphichai, Keith M Channon, Johann Pratschke, ManuelMaglione, Ernst R Werner 2014, 'Crucial role for neuronal nitric oxide synthase in early microcirculatory derangementand recipient survival following murine pancreas transplantation.', PLoS ONEhttp://europepmc.org/articles/PMC4229216?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Titin isoform bands with different sizes were separated on the gel.
Chaoqun Zhu, Wei Guo 2017, 'Detection and quantification of the giant protein titin by SDS-agarose gel electrophoresis',MethodsXhttp://www.sciencedirect.com/science/article/pii/S2215016117300377. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thus, glucose availability correlates with mhc isoform switching under all conditions investigated.
Martin E. Young, Jie Yan, Peter Razeghi, Robert C. Cooksey, Patrick H. Guthrie, StanislawM. Stepkowski, Donald A. McClain, Rong Tian, Heinrich Taegtmeyer M.D., D.Phil. 2007, 'Proposed Regulation of Gene Expression by Glucose in Rodent Heart', Gene Regulation and Systems Biologyhttps://doi.org/10.4137/GRSB.S222. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)