a drug, mepacrine dihydrochloride, one of the first synthetic substitutes for quinine, formerly widely used to treat malaria but now largely replaced by chloroquine. Formula: C23H30ClN3O.2HCl.2H2O
US name: quinacrine
Word origin
C20: from me(thyl) + pa(ludism + a)cr(id)ine
quinacrine in American English
(ˈkwɪnəˌkrin)
noun
Pharmacology
an alkaloid, C23H30ClN3O, similar in its properties to pamaquine, used in the treatment of malaria
Word origin
[1930–35; quin(ine) + acr(id) + -ine2]This word is first recorded in the period 1930–35. Other words that entered Englishat around the same time include: acoustic phonetics, hypercorrection, logical positivism, preset, uncertainty principle-ine is a suffix, of no assignable meaning, appearing in nouns of Greek, Latin, or Frenchorigin. Other words that use the affix -ine include: doctrine, famine, routine
Examples of 'quinacrine' in a sentence
quinacrine
Coxsackieviruses and echovirus were also inhibited by quinacrine in cultured cells.
Jianmin Wang, Jiang Du, Zhiqiang Wu, Qi Jin 2013, 'Quinacrine impairs enterovirus 71 RNA replication by preventing binding of polypyrimidine-tractbinding protein with internal ribosome entry sites.', PLoS ONEhttp://europepmc.org/articles/PMC3536785?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Apoptosis was markedly increased for cediranib/quinacrine/hypoxia versus all other groups.
Merryl R. Lobo, Xiaoyan Wang, G. Yancey Gillespie, Randall L. Woltjer, Martin M. Pike 2014, 'Combined Efficacy of Cediranib and Quinacrine in Glioma Is Enhanced by Hypoxia andCausally Linked to Autophagic Vacuole Accumulation', PLoS ONE10.1371/journal.pone.0114110. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The current study investigates the role of hypoxia and autophagy in combined cediranib/quinacrine efficacy.
Merryl R. Lobo, Xiaoyan Wang, G. Yancey Gillespie, Randall L. Woltjer, Martin M. Pike 2014, 'Combined Efficacy of Cediranib and Quinacrine in Glioma Is Enhanced by Hypoxia andCausally Linked to Autophagic Vacuole Accumulation', PLoS ONE10.1371/journal.pone.0114110. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A bacterial two-hybrid system was used to analyze the in vivo effect of quinacrineon the heterodimer complex.
Algevis P. Wrench, Christopher L. Gardner, Claudio F. Gonzalez, Graciela L. Lorca 2013, 'Identification of a Small Molecule That Modifies MglA/SspA Interaction and ImpairsIntramacrophage Survival of Francisella tularensis', PLoS ONE10.1371/journal.pone.0054498. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These were selected based on their structural similarity to quinacrine, which was previously reported to have anti-prion activity.
Erika Chung, Frances Prelli, Stephen Dealler, Woo Sirl Lee, Young-Tae Chang, ThomasWisniewski 2011, 'Styryl-based and tricyclic compounds as potential anti-prion agents.', PLoS ONEhttp://europepmc.org/articles/PMC3172287?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These findings provide a rationale for a clinical evaluation of combined cediranib/quinacrine therapy for malignant glioma.
Merryl R Lobo, Xiaoyan Wang, G Yancey Gillespie, Randall L Woltjer, Martin M Pike 2014, 'Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia andcausally linked to autophagic vacuole accumulation.', PLoS ONEhttp://europepmc.org/articles/PMC4260788?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In conclusion, quinacrine and cimetidine possess signifcant antiulcer and cytprotective activityagainst stress, and aspirin induced gastric lesions.
L BORJIAN, A.R RAHMANI 2002, 'COMPARSION OF PREVENTIVE EFFECT OF CIMETIDINE AND QUINACRINE ON STRESS AND ASPIRININDUCED PEPTIC ULCER', Journal of Research in Medical Scienceshttp://journals.mui.ac.ir/jrms/article/view/3248. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, inhibition of plasma membrane transporters or of the autophagic process with spautin-1 did not alter quinacrine transport parameters.
Alexandre Parks, Xavier Charest-Morin, Michael Boivin-Welch, Johanne Bouthillier,Francois Marceau 2015, 'Autophagic flux inhibition and lysosomogenesis ensuing cellular capture and retentionof the cationic drug quinacrine in murine models', PeerJhttps://peerj.com/articles/1314.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Quinacrine staining under fluorescence microscopy revealed numerous green, star-like spots in the cytoplasm of these cells.
Yating Peng, Jie Chen, Shan He, Jun Yang, Hao Wu 2012, 'Release of ATP from marginal cells in the cochlea of neonatal rats can be inducedby changes in extracellular and intracellular ion concentrations.', PLoS ONEhttp://europepmc.org/articles/PMC3468545?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)