Identification of the modifying factors involved in the adaptive response may provide candidates for radioprotection.
Tanya K. Day, Guoxin Zeng, Antony M. Hooker, Madhava Bhat, David R. Turner, PamelaJ. Sykes 2007, 'Extremely Low Doses of X-Radiation can Induce Adaptive Responses in Mouse Prostate',Dose-Responsehttps://doi.org/10.2203/dose-response.07-019.Day. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Recently, it has been shown to exert dual activities after irradiation, radioprotection, and radiosensitization.
Ki Moon Seong, Mira Yu, Kyu-Sun Lee, Sunhoo Park, Young Woo Jin, Kyung-Jin Min 2015, 'Curcumin Mitigates Accelerated Aging after Irradiation in Drosophila by Reducing OxidativeStress', BioMed Research Internationalhttp://dx.doi.org/10.1155/2015/425380. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Early studies showed radical scavenging, oxygen consumption and adsorption as mechanisms of melanin radioprotection.
Martyna Śniegocka, Ewa Podgórska, Przemysław M. Płonka, Martyna Elas, Bożena Romanowska-Dixon,Małgorzata Szczygieł, Michał A. Żmijewski, Mirosława Cichorek, Anna Markiewicz, AnnaA. Brożyna, Andrzej T. Słominski, Krystyna Urbańska 2018, 'Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitizationin Melanoma Radiotherapy—From Animal Models to Clinical Trials', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/19/4/1048. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Continued administration of nanocurcumin up to seven days post-irradiation resulted in no further radioprotection.
Reza Sadeghi, Abolfazl Razzaghdoust, Mohsen Bakhshandeh, Farinaz Nasirinezhad, BahramMofid 2019, 'Nanocurcumin as a radioprotective agent against radiation-induced mortality in mice',Nanomedicine Journalhttp://nmj.mums.ac.ir/article_12157_bb2e8beb53a62a7376b87f62e7e4dfbe.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
There are numerous studies indicating plant-based therapeutics against cancer and radioprotection.
Sakshi Painuli, Navin Kumar 2016, 'Prospects in the development of natural radioprotective therapeutics with anti-cancerproperties from the plants of Uttarakhand region of India', Journal of Ayurveda and Integrative Medicinehttp://www.sciencedirect.com/science/article/pii/S0975947616300122. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hence, the flavonoid structure, number and location of hydroxyl groups together determine the antioxidant and radioprotection mechanism.
Punit Bansal, Piya Paul, Pawan G. Nayak, Steve T. Pannakal, Jian-hua Zou, HartmutLaatsch, K.I. Priyadarsini, M.K. Unnikrishnan 2011, 'Phenolic compounds isolated from Pilea microphylla prevent radiation-induced cellularDNA damage', Acta Pharmaceutica Sinica Bhttp://www.sciencedirect.com/science/article/pii/S2211383511000864. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Its occurrence has been discussed during the implementation of new radiation techniques and justified appropriate radioprotection requirements.
C. Mirjolet, J.L. Merlin, G. Truc, G. Noël, J. Thariat, J. Domont, P. Sargos, S. Renard-Oldrini,I. Ray-Coquard, X. Liem, C. Chevreau, J.L. Lagrange, M.A. Mahé, F. Collin, F. Bonnetain,A. Bertaut, P. Maingon 2019, 'RILA blood biomarker as a predictor of radiation-induced sarcoma in a matched cohortstudyResearch in context', EBioMedicinehttp://www.sciencedirect.com/science/article/pii/S2352396419301094. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)