denoting a formulation of a medicinal drug taken orally that releases the active ingredients over several hours, in order to maintain a relatively constant plasma concentration of the drug
Also called: sustained-release, continuous-release
sustained-release in American English
(səˈsteindrɪˈlis)
adjective
Chemistry & Pharmacology(of a drug or fertilizer)
capable of gradual release of an active agent over a period of time, allowing for a sustained effect; timed-release; long-acting; prolonged-action; slow-release
Word origin
[1955–60]This word is first recorded in the period 1955–60. Other words that entered Englishat around the same time include: cassette, new wave, opioid, rite of passage, rollout
Examples of 'sustained-release' in a sentence
sustained-release
Most formulations showed sustained release profiles similar to that of a commercial sustained-release liquid based on ion exchange resin.
Maghraby Gamal Mohamed El, Elzayat Ehab Mostafa, Alanazi Fars Kaed 2014, 'Investigation of in situ gelling alginate formulations as a sustained release vehiclefor co-precipitates of dextromethrophan and Eudragit S 100', Acta Pharmaceuticahttp://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0002/acph-2014-0002.xml?format=INT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Curcumin showed sustained-release behavior from the nanofibers in vitro.
Liu J, Liu J, Xu H, Zhang Y, Chu L, Liu Q, Song N, Yang C 2013, 'Novel tumor-targeting, self-assembling peptide nanofiber as a carrier for effectivecurcumin delivery', International Journal of Nanomedicinehttp://www.dovepress.com/novel-tumor-targeting-self-assembling-peptide-nanofiber-as-a-carrier-f-a15367. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ligustrazine ethosome patches have a sustained-release property.
Liu X, Liu H, Zeng Z, Zhou W, Liu J, He Z 2011, 'Pharmacokinetics of ligustrazine ethosome patch in rats and anti-myocardial ischemiaand anti-ischemic reperfusion injury effect', International Journal of Nanomedicinehttp://www.dovepress.com/pharmacokinetics-of-ligustrazine-ethosome-patch-in-rats-and-anti-myoca-a7793. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In vitro release results showed sustained-release characteristics.
Zhao L, Wei Y, Huang Y, He B, Zhou Y, Fu J 2013, 'Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and invivo evaluation', International Journal of Nanomedicinehttp://www.dovepress.com/nanoemulsion-improves-the-oral-bioavailability-of-baicalin-in-rats-in--a14548. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The aging behavior of sustained-release microcapsules containing rejuvenator-modifiedasphalt can be greatly improved.
Xin Yan, Guotao Ning, Xiaofeng Wang, Tao Ai, Peng Zhao, Zhenjun Wang 2019, 'Preparation and Short-Term Aging Properties of Asphalt Modified by Novel Sustained-ReleaseMicrocapsules Containing Rejuvenator', Materialshttps://www.mdpi.com/1996-1944/12/7/1122. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Xanthan gum and guar gum were integrated in the sustained-release layer.
Sanjay Dey, Sankha Chattopadhyay, Bhaskar Mazumder 2014, 'Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive MatrixTablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release',BioMed Research Internationalhttp://dx.doi.org/10.1155/2014/396106. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Scores for other secondary efficacy variables were similar between the two sustained-release treatments.
Thipphawong John, Hanna Magdi 2008, 'A randomized, double-blind comparison of OROS® hydromorphone and controlled-releasemorphine for the control of chronic cancer pain', BMC Palliative Carehttp://www.biomedcentral.com/1472-684X/7/17. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Consequently, the sustained-release property was characterized by the kinetic parameters based on the cell-index.
Guojun Yan, Wei Sun, Yanfang Pei, Zhaogang Yang, Xiaobing Wang, Yuan Sun, ShangtianYang, Jinhuo Pan 2018, 'A novel release kinetics evaluation of Chinese compound medicine: Application of thexCELLigence RTCA system to determine the release characteristics of Sedum sarmentosumcompound sustained-release pellets', Saudi Pharmaceutical Journalhttp://www.sciencedirect.com/science/article/pii/S1319016417301457. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)