However, acacetin did not alter synaptosomal membrane potential.
Tzu-Yu Lin, Wei-Jan Huang, Chia-Chan Wu, Cheng-Wei Lu, Su-Jane Wang 2014, 'Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicityin rats.', PLoS ONEhttp://europepmc.org/articles/PMC3919813?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Synaptosomal mitochondria are a subgroup of neuronal mitochondria specifically locating at synapses.
Lu Wang, Lan Guo, Lin Lu, Huili Sun, Muming Shao, Simon J Beck, Lin Li, Janani Ramachandran,Yifeng Du, Heng Du 2016, 'Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease.',PLoS ONEhttp://europepmc.org/articles/PMC4778903?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Regulating the synaptosomal tau level might be a potential target for a therapeutic intervention directed at preventing neurodegeneration.
Naruhiko eSahara, Naruhiko eSahara, Miyuki eMurayama, Makoto eHiguchi, Suhara eTetsuya,Akihiko eTakashima, Akihiko eTakashima 2014, 'Biochemical distribution of tau protein in synaptosomal fraction of transgenic miceexpressing human P301L tau', Frontiers in Neurologyhttp://journal.frontiersin.org/Journal/10.3389/fneur.2014.00026/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Normalization of cognitive impairment was associated with reversal of cisplatin-induced synaptosomal mitochondrial deficits and restoration of synaptic integrity.
Jiacheng Ma, XiaoJiao Huo, Matthew B. Jarpe, Annemieke Kavelaars, Cobi J. Heijnen 2018, 'Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathologyas a result of cisplatin treatment', Acta Neuropathologica Communicationshttp://link.springer.com/article/10.1186/s40478-018-0604-3. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)