(ˌsɪndʒɪˈniːɪk, ˌsɪndʒɪˈneɪɪk) or syngenic (sɪnˈdʒɛnɪk)
adjective
with identical genes
syngeneic in American English
(ˌsɪndʒəˈniɪk)
adjective
designating or of genetically identical, or nearly identical, tissue, cells, etc.
see also allogeneic: sometimes called synˈgenic (sɪnˈdʒɛnɪk)
Examples of 'syngeneic' in a sentence
syngeneic
In contrast, syngeneic skin grafts are tolerated, and gray hair grows on the grafts.
Shogo Maeda, MD, Koichi Ueda, MD, PhD, Hidenori Yamana, MD, Junko Tashiro-Yamaji,PhD, Minenori Ibata, MD, PhD, Ayako Mikura, MD, PhD, Masashi Okada, MD, PhD, Emi Yasuda,MD, PhD, Yuro Shibayama, MD, PhD, Miya Yoshino, DDS, PhD, Takahiro Kubota, MD, PhD,Ryotaro Yoshida, MD, PhD 2015, 'Blood Supply--Susceptible Formation of Melanin Pigment in Hair Bulb Melanocytes ofMice', Plastic and Reconstructive Surgery, Global Openhttp://journals.lww.com/prsgo/Fulltext/2015/03000/Article.13.aspx. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This combination modality demonstrated to significantly reduce tumor growth in syngeneic melanoma tumor models.
Tessa Knox, Eva Sahakian, Debarati Banik, Melissa Hadley, Erica Palmer, Satish Noonepalle,Jennifer Kim, John Powers, Maria Gracia-Hernandez, Vasco Oliveira, Fengdong Cheng,Jie Chen, Cyril Barinka, Javier Pinilla-Ibarz, Norman H. Lee, Alan Kozikowski, AlejandroVillagra 2019, 'Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy bydecreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressiveproteins in tumor cells', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-019-42237-3. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this study, we developed and validated a syngeneic, metastatic, murine model of pancreatic cancer cachexia.
Stephanie H. Greco, Lena Tomkötter, Anne-Kristin Vahle, Rae Rokosh, Antonina Avanzi,Syed Kashif Mahmood, Michael Deutsch, Sara Alothman, Dalia Alqunaibit, Atsuo Ochi,Constantinos Zambirinis, Tasnima Mohaimin, Mauricio Rendon, Elliot Levie, Mridul Pansari,Alejandro Torres-Hernandez, Donnele Daley, Rocky Barilla, H. Leon Pachter, DanielTippens, Hassan Malik, Allal Boutajangout, Thomas Wisniewski, George Miller 2015, 'TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Modelof Pancreatic Cancer Cachexia', PLOS ONE10.1371/journal.pone.0132786. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Using a syngeneic murine splenic injection model, a significant decrease in liver metastasis burden was detected in vivo.
Katharina M. Schmidt, Peter Dietrich, Christina Hackl, Jessica Guenzle, Peter Bronsert,Christine Wagner, Stefan Fichtner-Feigl, Hans J. Schlitt, Edward K. Geissler, ClausHellerbrand, Sven A. Lang 2018, 'Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis', Neoplasia: An International Journal for Oncology Researchhttp://www.sciencedirect.com/science/article/pii/S1476558618303609. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This test detects inherent and acquired resistance in vitro and transplantable syngeneic and xenografted tumors in vivo.
Manfred eVolm, Thomas eEfferth 2015, 'Prediction of Cancer Drug Resistance and Implications for Personalized Medicine.',Frontiers in Oncologyhttp://journal.frontiersin.org/Journal/10.3389/fonc.2015.00282/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Syngeneic models with intraocular injection of cutaneous melanoma cells may suit best for investigating immunologic/tumor biology aspects.
Marta M. Stei, Karin U. Loeffler, Frank G. Holz, Martina C. Herwig 2016, 'Animal Models of Uveal Melanoma: Methods, Applicability, and Limitations', BioMed Research Internationalhttp://dx.doi.org/10.1155/2016/4521807. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The syngeneic recipients of liver grafts were also treated with or without nitrite by intra-peritoneal injection.
Wei Li, Zihui Meng, Yuliang Liu, Rakesh P. Patel, John D. Lang 2012, 'The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury',Journal of Transplantationhttp://dx.doi.org/10.1155/2012/635179. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Overall, these studies provide an important resource to enhance our translation of syngeneic models to human tumors.
Jong W Yu, Sabyasachi Bhattacharya, Niranjan Yanamandra, David Kilian, Hong Shi, SapnaYadavilli, Yuliya Katlinskaya, Heather Kaczynski, Michael Conner, William Benson,Ashleigh Hahn, Laura Seestaller-Wehr, Meixia Bi, Nicholas J Vitali, Lyuben Tsvetkov,Wendy Halsey, Ashley Hughes, Christopher Traini, Hui Zhou, Junping Jing, Tae Lee,David J Figueroa, Sara Brett, Christopher B Hopson, James F Smothers, Axel Hoos, RoopaSrinivasan 2018, 'Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanisticstudies and predict therapy response in distinct tumor microenvironments.', PLoS ONEhttp://europepmc.org/articles/PMC6214511?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In our in vivo syngeneic model of mesothelioma, a highly selective accumulation of the particles in the tumor was obtained.
Philippe Bertrand, Christophe Blanquart, Valérie Héroguez 2019, 'The ROMP: A Powerful Approach to Synthesize Novel pH-Sensitive Nanoparticles for TumorTherapy', Biomoleculeshttps://www.mdpi.com/2218-273X/9/2/60. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)