The mechanisms that abrogate the prophase arrest in mammalian oocytes and reinitiate meiosis are not well understood.
Thomas Tischer, Melina Schuh 2016, 'The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in MouseOocytes', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124716313936. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Moreover, the decision to reinitiate nivolumab treatment requires careful judgment in future instances of cancer recurrence.
Susumu Noguchi, Hiroaki Kawachi, Hiroshi Yoshida, Akari Fukao, Satoshi Terashita,Tatsuyoshi Ikeue, Sadao Horikawa, Takakazu Sugita 2018, 'Sarcoid-Like Granulomatosis Induced by Nivolumab Treatment in a Lung Cancer Patient',Case Reports in Oncologyhttps://www.karger.com/Article/FullText/492383. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Targeted interventions should focus on patients who are nonadherent or who stop treatment without intention to reinitiate.
Zimmer A, Coslovsky M, Abraham I, Décard BF 2017, 'Adherence to fingolimod in multiple sclerosis: an investigator-initiated, prospective,observational, single-center cohort study', Patient Preference and Adherencehttps://www.dovepress.com/adherence-to-fingolimod-in-multiple-sclerosis-an-investigator-initiate-peer-reviewed-article-PPA. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)