We are unable to detect sumoylation of the related proteins lipin-2 and lipin-3.
Guang-Hui Liu, Larry Gerace 2009, 'Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.', PLoS ONEhttp://europepmc.org/articles/PMC2737637?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This research provides evidence for the mechanism of lipin expression in the liver.
Takashi Obama, Sayaka Nagaoka, Kazuki Akagi, Rina Kato, Naomi Horiuchi, Yasushi Horai,Toshihiro Aiuchi, Satoru Arata, Tomohiro Yamaguchi, Mitsuhiro Watanabe, Hiroyuki Itabe 2011, 'Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice:suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.', PLoS ONEhttp://europepmc.org/articles/PMC3153461?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It remains unknown how the nuclear localization and coactivator functions of lipin-1 are regulated.
Guang-Hui Liu, Larry Gerace 2009, 'Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.', PLoS ONEhttp://europepmc.org/articles/PMC2737637?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Studies of anti-inflammatory therapy may be indicated in lipin-1 deficiency.
I.A. Meijer, F. Sasarman, C. Maftei, E. Rossignol, M. Vanasse, P. Major, G.A. Mitchell,C. Brunel-Guitton 2015, 'LPIN1 deficiency with severe recurrent rhabdomyolysis and persistent elevation ofcreatine kinase levels due to chromosome 2 maternal isodisomy', Molecular Genetics and Metabolism Reportshttp://www.sciencedirect.com/science/article/pii/S2214426915300458. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the regulatory mechanisms for the expression of lipin in the liver are notwell understood.
Takashi Obama, Sayaka Nagaoka, Kazuki Akagi, Rina Kato, Naomi Horiuchi, Yasushi Horai,Toshihiro Aiuchi, Satoru Arata, Tomohiro Yamaguchi, Mitsuhiro Watanabe, Hiroyuki Itabe 2011, 'Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice:suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.', PLoS ONEhttp://europepmc.org/articles/PMC3153461?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)