The translational obstacles of liposomal technology will also be presented.
Lisa eSercombe, Tejaswi eVeerati, Tejaswi eVeerati, Fatemeh eMohemani, Sherry Y Wu,Anil eSood, Anil eSood, Anil eSood, Susan eHua 2015, 'Advances and Challenges of Liposome Assisted Drug Delivery', Frontiers in Pharmacologyhttp://journal.frontiersin.org/Journal/10.3389/fphar.2015.00286/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Optimum liposomal formulations were established using this method for enhancing their characteristics.
Farhad Kiafar, Mohammad Reza Siahi Shadbad, Hadi Valizadeh 2016, 'Filgrastim (G-CSF) loaded liposomes: mathematical modeling and optimization of encapsulationefficiency and particle size', BioImpactshttp://bi.tbzmed.ac.ir/PDF/bi-6-195.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Liposomal magnetofection provided high efficiency in transgene expression in vivo.
Yiping Xu, Xuebiao Li, Minjian Kong, Daming Jiang, Aiqiang Dong, Zhonghua Shen, QunjunDuan 2014, 'Cardiac-targeting magnetic lipoplex delivery of SH-IGF1R plasmid attenuate norepinephrine-inducedcardiac hypertrophy in murine heart', Bioscience Reportshttp://www.bioscirep.org/bsr/034/e140/bsr034e140.htm. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Data from the first 50 patients treated with carboplatin plus pegylated liposomal doxorubicin were evaluated.
D'Arco Alfonso, Musso Pietro, Ferro Antonella, Naglieri Emanuele, Del Gaizo Filomena,Natale Donato, Gebbia Vittorio, Rossi Emanuela, De Vivo Rocco, Scollo Paolo, BredaEnrico, Savarese Antonella, Scambia Giovanni, Pignata Sandro, Sorio Roberto, PisanoCarmela, Di Maio Massimo, Signoriello Giuseppe, Annunziata Annalisa, Perrone Francesco 2006, 'Safety of a 3-weekly schedule of carboplatin plus pegylated liposomal doxorubicinas first line chemotherapy in patients with ovarian cancer: preliminary results ofthe MITO-2 randomized trial', BMC Cancerhttp://www.biomedcentral.com/1471-2407/6/202. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Impact of pegylation on liposomal surface and relevance of positive or negative charge were assessed.
Minghan Shi, Malathi Anantha, Mohamed Wehbe, Marcel B. Bally, David Fortin, Laurent-OlivierRoy, Gabriel Charest, Maxime Richer, Benoit Paquette, Léon Sanche 2018, 'Liposomal formulations of carboplatin injected by convection-enhanced delivery increasesthe median survival time of F98 glioma bearing rats', Journal of Nanobiotechnologyhttp://link.springer.com/article/10.1186/s12951-018-0404-8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Furthermore, liposomal formulations prevent the biofilm-formation ability of these strains better than free gentamicin.
Alhariri M, Majrashi MA, Bahkali AH, Almajed FS, Azghani AO, Khiyami MA, AlyamaniEJ, Aljohani SM, Halwani MA 2017, 'Efficacy of neutral and negatively charged liposome-loaded gentamicin on planktonicbacteria and biofilm communities', International Journal of Nanomedicinehttps://www.dovepress.com/efficacy-of-neutral-and-negatively-charged-liposome-loaded-gentamicin--peer-reviewed-article-IJN. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The increase in liposomal fluidity resulted in the increased skin penetration of sodium fluorescein.
Subongkot T, Ngawhirunpat T 2015, 'Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped inliposomes', International Journal of Nanomedicinehttp://www.dovepress.com/effect-of-liposomal-fluidity-on-skin-permeation-of-sodium-fluorescein--peer-reviewed-article-IJN. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases.
Luigi Ambrosone, Germano Guerra, Mariapia Cinelli, Mariaelena Filippelli, Monica Mosca,Francesco Vizzarri, Dario Giorgio, Ciro Costagliola 2014, 'Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops',BioMed Research Internationalhttp://dx.doi.org/10.1155/2014/471642. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Treatment was initiated with liposomal doxorubicin resulting in rapid improvement of the skin lesions.
Daniel Cornett, Mark Benson, Steven Attia, Jennifer Weiss, Deepak Gopal 2011, 'Metastatic Kaposi's Sarcoma with Perirectal Involvement Diagnosed with EndoscopicUltrasound-Guided EchoBrush Cytology Sampling', Case Reports in Gastroenterologyhttp://www.karger.com/Article/FullText/330480. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)