a potent cytotoxic substance, C6H14O6S2, used in the treatment of chronic myeloid leukemia
Word origin
[1955–60; bu(tanediol dimethane) sulf(onate) its chemical name + -an perh. orig. var. of -ane]This word is first recorded in the period 1955–60. Other words that entered Englishat around the same time include: backgrounder, cassette, life-support, new wave, rollout
Examples of 'busulfan' in a sentence
busulfan
Notably, all three doses of busulfan were tolerated well without significant extra-medullary toxicity.
Nadim Mahmud, Amit Khanal, Simona Taioli, Emre Koca, Sujata Gaitonde, Benjamin Petro,Karen Sweiss, Lisa Halliday, Xinhe Wang, Pritesh Patel, Damiano Rondelli 2018, 'Preclinical IV busulfan dose-finding study to induce reversible myeloablation in anon-human primate model.', PLoS ONEhttp://europepmc.org/articles/PMC6264479?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The conditioning therapy included busulfan (16 mg/kg) and cyclophosphamide (200 mg/kg).
Nicoletta Iacovidou, Maria Kollia, Emmeleia Nana, Theodora Boutsikou, Christos Savvidis,Antonis Kattamis, Dimitra Kyriakopoulou, Vassilis Ladis 2017, 'Spontaneous fertility in a male thalassemic patient after allogeneic hematopoieticcell transplantation', Thalassemia Reportshttp://www.pagepressjournals.org/index.php/thal/article/view/7090. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In contrast, the effect of busulfan on hemoglobin levels was mild.
Nadim Mahmud, Amit Khanal, Simona Taioli, Emre Koca, Sujata Gaitonde, Benjamin Petro,Karen Sweiss, Lisa Halliday, Xinhe Wang, Pritesh Patel, Damiano Rondelli 2018, 'Preclinical IV busulfan dose-finding study to induce reversible myeloablation in anon-human primate model', PLOS ONE10.1371/journal.pone.0206980. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Another group received 10 mg/kg busulfan and was fed with pellet containing 10% bene.
Hojat Norasteh, Shabnam Mohammadi, Mohammad Reza Nikravesh, Samaneh Broumand, FarimahBeheshti 2019, 'Effects of Bene (Pistacia atlantica) on Histopathology of Testis, Sperm ChromatinQuality and Stress Oxidative in Busulfan-Induced Infertile Mice', Pharmaceutical Scienceshttps://ps.tbzmed.ac.ir/PDF/PHARM_1738_20180622101711. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The most common conditioning regimens were cyclophosphamide + busulfan.
A. Mousavi, L. Nedaeifard, M. Iravani, K. Alimoghaddam, B. Bahar, M. Jahani, A. AshouriA. Ghavamzadeh 2008, 'RESULTS OF HEMATOPOIETIC CELL TRANSPLANTATION IN PEDIATRIC LEUKEMIA', Acta Medica Iranicahttp://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5980.pdf&manuscript_id=5980. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Blood analysis shows that the toxicity of busulfan treated groups was much lower than i.p.
YuSheng Qin, Ling Liu, YaNan He, Chen Wang, MingYuan Liang, XiaoLi Chen, HaiShengHao, Tong Qin, XueMing Zhao, Dong Wang 2016, 'Testicular Busulfan Injection in Mice to Prepare Recipients for Spermatogonial StemCell Transplantation Is Safe and Non-Toxic.', PLoS ONEhttp://europepmc.org/articles/PMC4752460?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The busulfan group was injected a single dose of 10 mg/kg busulfan intraperitoneally.
Azadeh Vafaei, Shabnam Mohammadi, Alireza Fazel, Mohammad Soukhtanloo, Abbas Mohammadipour,Farimah Beheshti 2018, 'Effects of Carob (Ceratonia siliqua) on Sperm Quality, Testicular Structure, TestosteroneLevel and Oxidative Stress in Busulfan-Induced Infertile Mice', Pharmaceutical Scienceshttp://journals.tbzmed.ac.ir/PHARM/Manuscript/PHARM-24-104.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Recently, the development of busulfan pre-conditioning of animals improved the flexibility of experimentation in comparison with irradiation.
Jean Chevaleyre, Pascale Duchez, Laura Rodriguez, Marija Vlaski, Arnaud Villacreces,Véronique Conrad-Lapostolle, Vincent Praloran, Zoran Ivanovic, Philippe Brunet dela Grange 2013, 'Busulfan administration flexibility increases the applicability of scid repopulatingcell assay in NSG mouse model.', PLoS ONEhttp://europepmc.org/articles/PMC3775811?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)