The article describes a two-step synthesis of diastereomeric 3-hydroxy-2-methyl-3-(4-biphenylyl)butanoic acids.
Ivan O. Juranic, Sote M. Vladimirov, Bojan D. Markovic, Zorica D. Juranic, Silva Lj.Dobric, Sanda P. Dilber 2008, 'Docking Studies and Anti-inflammatory Activity of β-Hydroxy-β-arylpropanoicAcids', Moleculeshttp://www.mdpi.com/1420-3049/13/3/603/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Reaction of 4-oxo-4-(3,4-dichlorophenyl)-2-butenoic acid (1) with antipyrin (2) gave the corresponding butanoic acid 3.
M. Shafik, W. E. Boraie, G. A. Meligi, A. A. Hamed, G. H. Sayed 2003, 'The Use of 4-(3,4-Dichlorophenyl)-4-Oxo-2-(4-Antipyrinyl)-Butanoic Acid in the Preparationof Some New Heterocyclic Compounds With Expected Biological Activity', Moleculeshttp://www.mdpi.com/1420-3049/8/3/322/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We have also found significant differences concerning the contents of pentadecane, 1-hexanol-2 ethyl, butanoic acid, furano-2-penthyl.
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