In conclusion, the presence of biofilms did not influence the treatment outcomes of anticaries products.
Patrícia Regina Almeida de Oliveira, Thereza Christina Lopes Coutinho, Maristela BarbosaPortela, Viviane Cancio Andrade de Paula, Mônica Almeida Tostes 2017, 'Influence of biofilm formation on the mechanical properties of enamel after treatmentwith CPP-ACP crème', Brazilian Oral Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242017000100275&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, further investigations are suggested to understand the anticaries properties of these pure compounds.
Hamzah Abdulrahman Salman, Sankarasetty Venkatesh, Ramasamy Senthilkumar, B S GnaneshKumar, Aamer Mousa Ali 2018, 'Determination of antibacterial activity and metabolite profile of Ruta graveolensagainst Streptococcus mutans and Streptococcus sobrinus', Journal of Laboratory Physicianshttp://www.jlponline.org/article.asp?issn=0974-2727;year=2018;volume=10;issue=3;spage=320;epage=325;aulast=Salman. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ion-releasing polymeric restorative materials seem to be promising solutions, due to their possible anticaries effect.
Krzysztof Sokolowski, Agata Szczesio-Wlodarczyk, Kinga Bociong, Michal Krasowski,Magdalena Fronczek-Wojciechowska, Monika Domarecka, Jerzy Sokolowski, Monika Lukomska-Szymanska 2018, 'Contraction and Hydroscopic Expansion Stress of Dental Ion-Releasing Polymeric Materials',Polymershttp://www.mdpi.com/2073-4360/10/10/1093. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The low salivary fluoride levels may thereby reduce the anticaries efficacy.
Nagpal D, Damle S 2007, 'Comparison of salivary fluoride levels following use of dentifrices containing differentconcentrations of fluoride', Journal of Indian Society of Pedodontics and Preventive Dentistryhttp://www.jisppd.com/article.asp?issn=0970-4388;year=2007;volume=25;issue=1;spage=20;epage=22;aulast=Nagpal. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thus, natural products should be explored for their anticaries action.
Deepika Jain, Pralhad Dasar, Sandesh Nagarajappa, Sandeep Kumar, Bhuvnesh Airen, ShilpaWarhekar 2014, 'In vitro activity of ethanolic and water extract of guava leaves at various concentrationsagainst Lactobacillus acidophilus', Journal of Indian Association of Public Health Dentistryhttp://www.jiaphd.org/article.asp?issn=2319-5932;year=2014;volume=12;issue=3;spage=232;epage=236;aulast=Jain. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Despite advances in the development of anticaries chemotherapy, the newer agents are unable to control the initiation of dental caries.
Amit R Kankariya, Alok R Patel, Sanket S Kunte 2016, 'The effect of different concentrations of water soluble azadirachtin (neem metabolite)on Streptococcus mutans compared with chlorhexidine', Journal of Indian Society of Pedodontics and Preventive Dentistryhttp://www.jisppd.com/article.asp?issn=0970-4388;year=2016;volume=34;issue=2;spage=105;epage=110;aulast=Kankariya. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Salivary fluoride levels after tooth-brushing have been shown to be related to theanticaries efficacy of fluoride dentifrices.
Nagpal D, Damle S 2007, 'Comparison of salivary fluoride levels following use of dentifrices containing differentconcentrations of fluoride', Journal of Indian Society of Pedodontics and Preventive Dentistryhttp://www.jisppd.com/article.asp?issn=0970-4388;year=2007;volume=25;issue=1;spage=20;epage=22;aulast=Nagpal. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Health-associated oral streptococci are promising candidates for anticaries probiotics, but strains need to be carefully selected based on observed phenotypes.
Irina M. Velsko, Brinta Chakraborty, Marcelle M. Nascimento, Robert A. Burne, VincentP. Richards 2018, 'Species Designations Belie Phenotypic and Genotypic Heterogeneity in Oral Streptococci',mSystemshttps://doi.org/10.1128/mSystems.00158-18. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)