the compound C10H12O4, which is the active ingredient in cantharides and is secreted by many species of blister beetle
Examples of 'cantharidin' in a sentence
cantharidin
Results revealed that the two strains maintained a relatively high-level susceptibility to cantharidin.
Zhengyu Huang, Yalin Zhang 2015, 'Chronic Sublethal Effects of Cantharidin on the Diamondback Moth Plutella xylostella(Lepidoptera: Plutellidae)', Toxinshttp://www.mdpi.com/2072-6651/7/6/1962. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This study aims to investigate the effects of cantharidin on pancreatic cancer xenografts in vivo.
Meng-Dan Xu, Lu Liu, Meng-Yao Wu, Min Jiang, Liu-Mei Shou, Wen-Jie Wang, Jing Wu,Yan Zhang, Fei-Ran Gong, Kai Chen, Min Tao, Qiaoming Zhi, Wei Li 2018, 'The combination of cantharidin and antiangiogenic therapeutics presents additive antitumoreffects against pancreatic cancer', Oncogenesishttp://link.springer.com/article/10.1038/s41389-018-0102-2. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cantharidin: 12.5μl of 0.1% cantharidin elicited a single blister, aspirated at 24 hours.
Alexander A. Maini, Marc J. George, Madhur P. Motwani, Richard M. Day, Derek W. Gilroy,Alastair J. O'Brien 2016, 'A Comparison of Human Neutrophils Acquired from Four Experimental Models of Inflammation',PLOS ONE10.1371/journal.pone.0165502. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cantharidin also significantly increased apoptosis-related signals, including caspase-9,caspase-7 and caspase-3 proteins.
Chin-Chuan Su, Kuan-I Lee, Mu-Kuan Chen, Chun-Ying Kuo, Chih-Hsin Tang, Shing HwaLiu 2016, 'Cantharidin Induced Oral Squamous Cell Carcinoma Cell Apoptosis via the JNK-RegulatedMitochondria and Endoplasmic Reticulum Stress-Related Signaling Pathways.', PLoS ONEhttp://europepmc.org/articles/PMC5145211?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Putative genes and pathways involved in the biosynthesis of cantharidin were then characterized.
Yi Huang, Zhongkang Wang, Shenfang Zha, Yu Wang, Wei Jiang, Yufeng Liao, ZhangyongSong, Zhaoran Qi, Youping Yin 2016, 'De Novo Transcriptome and Expression Profile Analysis to Reveal Genes and PathwaysPotentially Involved in Cantharidin Biosynthesis in the Blister Beetle Mylabris cichorii',PLOS ONE10.1371/journal.pone.0146953. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Furthermore, cantharidin reduced pro-caspase-12 protein expression.
Chin-Chuan Su, Kuan-I Lee, Mu-Kuan Chen, Chun-Ying Kuo, Chih-Hsin Tang, Shing HwaLiu 2016, 'Cantharidin Induced Oral Squamous Cell Carcinoma Cell Apoptosis via the JNK-RegulatedMitochondria and Endoplasmic Reticulum Stress-Related Signaling Pathways.', PLoS ONEhttp://europepmc.org/articles/PMC5145211?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Researches in vitro have shown that cantharidin suppresses cell viability and metastasis in pancreatic cancer cells.
Meng-Dan Xu, Lu Liu, Meng-Yao Wu, Min Jiang, Liu-Mei Shou, Wen-Jie Wang, Jing Wu,Yan Zhang, Fei-Ran Gong, Kai Chen, Min Tao, Qiaoming Zhi, Wei Li 2018, 'The combination of cantharidin and antiangiogenic therapeutics presents additive antitumoreffects against pancreatic cancer', Oncogenesishttp://link.springer.com/article/10.1038/s41389-018-0102-2. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We therefore carried out an extensive characterisation of the cantharidin skin blister model in healthy male volunteers.
William Jenner, Madhur Motwani, Kristin Veighey, Justine Newson, Tatsiana Audzevich,Anna Nicolaou, Sharon Murphy, Raymond Macallister, Derek W Gilroy 2014, 'Characterisation of leukocytes in a human skin blister model of acute inflammationand resolution.', PLoS ONEhttp://europepmc.org/articles/PMC3945731?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)