a cholinergic agent, C6H15ClN2O2, used for various ophthalmic purposes, such as the treating of glaucoma
Examples of 'carbachol' in a sentence
carbachol
Bladder histology, urodynamics and contractile responses to field stimulation and carbachol were determined.
Liucheng Ding, Tao Song, Chaoran Yi, Yi Huang, Wen Yu, Lin Ling, Yutian Dai, ZhongqingWei 2013, 'Transcutaneous electrical nerve stimulation (TENS) improves the diabetic cytopathy(DCP) via up-regulation of CGRP and cAMP.', PLoS ONEhttp://europepmc.org/articles/PMC3585412?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Carbachol alone showed no effect on the tested ion channel currents.
Zhihan Zhao, Huan Lan, Ibrahim El-Battrawy, Xin Li, Fanis Buljubasic, Katherine Sattler,Gökhan Yücel, Siegfried Lang, Malte Tiburcy, Wolfram-Hubertus Zimmermann, Lukas Cyganek,Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiao-Bo Zhou, Ibrahim Akin 2018, 'Ion Channel Expression and Characterization in Human Induced Pluripotent Stem Cell-DerivedCardiomyocytes', Stem Cells Internationalhttp://dx.doi.org/10.1155/2018/6067096. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
When carbachol was applied over the urothelium-denuded bladder, the assay ureter contraction rate was unaltered.
Na N. Guan, Anna Thor, Katarina Hallén, N. Peter Wiklund, Lars E. Gustafsson 2014, 'Cascade Bioassay Evidence for the Existence of Urothelium-Derived Inhibitory Factorin Guinea Pig Urinary Bladder', PLoS ONE10.1371/journal.pone.0103932. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These differences were apparent with three agonists: acetylcholine, carbachol, and nicotine.
Nyresa C Alves, Craig D C Bailey, Raad Nashmi, Evelyn K Lambe 2010, 'Developmental sex differences in nicotinic currents of prefrontal layer VI neuronsin mice and rats.', PLoS ONEhttp://europepmc.org/articles/PMC2822857?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Atropine caused the shift of curves for carbachol to the right.
Izabela Glaza, Leszek Szadujkis-Szadurski, Rafał Szadujkis-Szadurski, Marta Gajdus,Joanna Olkowska 2011, 'Modulating activity of M1 receptor to the reaction of ileal smooth muscle', Postępy Higieny i Medycyny Doświadczalnejhttp://journals.indexcopernicus.com/fulltxt.php?ICID=954785. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Moreover, the crude water extract showed a significant antagonistic effect on carbachol-induced tracheal contraction.
Prasettho, S., Dajawong, A., Wongnawa, M., Sanbhanich, M. 1999, 'Effect of water extract of Randia siamensis Criab. on guinea-pig trachealsmooth muscle', Songklanakarin Journal of Science and Technology (SJST)http://www.sjst.psu.ac.th/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Explanted tissue was tested for contractile responses to carbachol and histamine.
Richard C. Kurten, Renee Rawson, Tetsuo Shoda, Loan D. Duong, Dolapo Adejumobi, RebeccaLevy, Robert O. Newbury, Marc E. Rothenberg, Praveen Akuthota, Benjamin L. Wright,Ranjan Dohil, Stacie M. Jones, Seema S. Aceves 2019, 'Development and Application of a Functional Human Esophageal Mucosa Explant Platformto Eosinophilic Esophagitis', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-019-41147-8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Carbachol also induced early signalling cascades similar to previous reports.
E. Scott Graham, Kerhan K. Woo, Miranda Aalderink, Sandie Fry, Jeffrey M. Greenwood,Michelle Glass, Mike Dragunow 2013, 'M1 Muscarinic Receptor Activation Mediates Cell Death in M1-HEK293 Cells', PLoS ONE10.1371/journal.pone.0072011. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All antagonists competitively antagonized concentration–response curves to carbachol with high affinities in normal bladder.
Tomonori Yamanishi, Kanya Kaga, Miki Fuse, Chiharu Shibata, Takao Kamai, TomoyukiUchiyama 2015, 'The role of muscarinic receptor subtypes on carbachol-induced contraction of normalhuman detrusor and overactive detrusor associated with benign prostatic hyperplasia',Journal of Pharmacological Scienceshttp://www.sciencedirect.com/science/article/pii/S1347861315001036. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All subjects were submitted to bronchial provocation with carbachol.
Mônica Silveira Lapa, Roberto Rodrigues Júnior, Elie Fiss 2005, 'Estudo da hiper-responsividade brônquica em pacientes portadores de refluxo gastroesofágicoBronchial hyperreactivity in patients with gastroesophageal reflux disease', Jornal Brasileiro de Pneumologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132005000400004. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)