an enzyme in blood cells that catalyses the decomposition of carbonic acid into carbon dioxide and water, facilitating the transport of carbon dioxide from the tissues to the lungs
carbonic anhydrase in American English
(ænˈhaidreis, -dreiz)
noun
Biochemistry
an enzyme that catalyzes the reversible combination of carbon dioxide with water in red blood cells
Word origin
[1835–45; anhydr- + -ase]This word is first recorded in the period 1835–45. Other words that entered Englishat around the same time include: crosshead, daisy chain, ecumenical, grandstand, hybridize-ase is a suffix used in the names of enzymes. Other words that use the affix -ase include: amylase, invertase, lipase, oxidase, phosphorylase
Examples of 'carbonic anhydrase' in a sentence
carbonic anhydrase
Local carbonic anhydrase inhibitors changed slightly.
Xiu-Juan Guo, Di Chen, Hai-Xia Wu, Yuan-Bo Liang, Shu-Ke Luo 2018, 'Retrospective study of topical medical treatment for glaucoma', Guoji Yanke Zazhihttp://ies.ijo.cn/cn_publish/2018/10/201810034.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ibuprofen causes renal tubular acidosis due to its effects on carbonic anhydrase activity.
M. J. Blackstock, A. Lee 2012, 'Hypokalaemia and Renal Tubular Acidosis due to Abuse of Nurofen Plus', Case Reports in Critical Carehttp://dx.doi.org/10.1155/2012/141505. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Contents of photosynthetic pigments and activity of nitrate reductase, carbonic anhydrase enzymes were also significantly enhanced.
Tariq Ahmad Dar, Moin Uddin, M. Masroor A. Khan, Akbar Ali, Suhail Rasool Mir, LalitVarshney 2015, 'Effect of Co-60 gamma irradiated chitosan and phosphorus fertilizer on growth, yieldand trigonelline content of Trigonella foenum-graecum L.', Journal of Radiation Research and Applied Scienceshttp://www.sciencedirect.com/science/article/pii/S1687850715000552. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Prostaglandin analogs and beta blockers, alone or combined with carbonic anhydrase inhibitors, were the preferred medications.
Otzem Chassid, Irena Epstein, Adi Sharabi-Nov, Joseph Pikkel 2018, 'Prevalence of glaucoma in the Israeli Arab population', International Journal of Ophthalmologyhttp://www.ijo.cn/en_publish/2018/1/20180125.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the carbonic anhydrase inhibitor acetazolamide had the largest effect onthe profile of lipophilic metabolites.
Anissa Belkaid, Miroslava Čuperlović-Culf, Mohamed Touaibia, Rodney J. Ouellette,Marc E. Surette 2016, 'Metabolic Effect of Estrogen Receptor Agonists on Breast Cancer Cells in the Presenceor Absence of Carbonic Anhydrase Inhibitors', Metaboliteshttp://www.mdpi.com/2218-1989/6/2/16. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Post-operative treatment consisted of systemic meloxicam and topical carbonic anhydrase inhibitors, beta-blockers and prostaglandins analogues.
Pierre-François Isard, Marielle Mentek, David Clément, Aurélie Béglé, Fabrice Romano,Florent Aptel, Iona Mathieson, Thomas Dulaurent 2018, 'High intensity focused ultrasound cyclocoagulation in dogs with primary glaucoma:a preliminary study', Open Veterinary Journalhttps://www.openveterinaryjournal.com/OVJ-2018-02-025%20P.F.%20Isard%20et%20al.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Among these proteins are known biomineralization compounds, such as carbonic anhydrase, spherulin, extracellular matrix proteins and very acidic proteins.
Juliane Germer, Karlheinz Mann, Gert Wörheide, Daniel John Jackson 2015, 'The Skeleton Forming Proteome of an Early Branching Metazoan: A Molecular Survey ofthe Biomineralization Components Employed by the Coralline Sponge Vaceletia Sp.',PLOS ONE10.1371/journal.pone.0140100. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
For more than 50 years acetozolamide, systemic carbonic anhydrase inhibitor, has beenused in neurology to correct liquorodynamic disorders.
A.N. Boyko, E.I. Gusev, O.V. Bykova, L.M. Kuzenkova, O.I. Maslova 2006, 'ACETAZOLAMIDE IN PEDIATRIC NEUROLOGY: HISTORY AND PERSPECTIVE OF CILNICAL USE', Voprosy Sovremennoj Pediatriihttp://vsp.spr-journal.ru:80/jour/article/view/735. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This study sought to demonstrate the feasibility of detecting carbonic anhydrase activity in the human brain in vivo.
Shizhe Li, Li An, Qi Duan, Maria Ferraris Araneta, Christopher S. Johnson, Jun Shen 2018, 'Determining the Rate of Carbonic Anhydrase Reaction in the Human Brain', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-20746-x. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The carbonylation status of carbonic anhydrase-2, selenium binding protein, and peroxiredoxin-6 was higher in control lung tissue.
Michal Barshishat-Kupper, Elizabeth A. McCart, James G. Freedy, Ashlee J. Tipton,Vitaly Nagy, Sung-Yop Kim, Michael R. Landauer, Gregory P. Mueller, Regina M. Day 2015, 'Protein Oxidation in the Lungs of C57BL/6J Mice Following X-Irradiation', Proteomeshttp://www.mdpi.com/2227-7382/3/3/249. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)