of or pertaining to certain substances capable of arresting the process of cell division
noun
2.
any such substance, as certain drugs used to destroy cancer cells
Word origin
[1965–70; anti- + mitotic]This word is first recorded in the period 1965–70. Other words that entered Englishat around the same time include: Finlandization, hired gun, overdub, stun gun, wraparoundanti- is a prefix meaning “against,” “opposite of,” “antiparticle of,” used in the formationof compound words (anticline); used freely in combination with elements of any origin (antibody; antifreeze; antiknock; antilepton)
Examples of 'antimitotic' in a sentence
antimitotic
Micelle antimitotic activity was compared with the activity of the corresponding free glycosides.
Hugo Groult, Isabel García-Álvarez, Lorenzo Romero-Ramírez, Manuel Nieto-Sampedro,Fernando Herranz, Alfonso Fernández-Mayoralas, Jesús Ruiz-Cabello 2018, 'Micellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides', Nanomaterialshttp://www.mdpi.com/2079-4991/8/8/567. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antimitotic agents are frequently used to treat solid tumors and hematologic malignancies.
Dominik Schnerch, Marie Follo, Julia Felthaus, Monika Engelhardt, Ralph Wäsch 2013, 'The 3' untranslated region of the cyclin B mRNA is not sufficient to enhance the synthesisof cyclin B during a mitotic block in human cells.', PLoS ONEhttp://europepmc.org/articles/PMC3772928?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The endosymbiont produces the antimitotic macrolide rhizoxin for its host.
Boland Sebastian, Partida-Martinez Laila P, Moebius Nadine, Lackner Gerald, HertweckChristian 2011, 'Evolution of an endofungal Lifestyle: Deductions from the Burkholderia rhizoxinicaGenome', BMC Genomicshttp://www.biomedcentral.com/1471-2164/12/210. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antimitotic agents routinely cause alopecia.
K B Gupta, V Kumar, S Vishvkarma, R Shandily 2011, 'Isoniazid-induced alopecia', Lung Indiahttp://www.lungindia.com/article.asp?issn=0970-2113;year=2011;volume=28;issue=1;spage=60;epage=61;aulast=Gupta. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this study, we examined the antiproliferative activity and obtained the antimitotic compound of ongkea cortex.
Muh. Akbar Bahar, Gemini Alam, Marianti A. Manggau, Mufidah Mufidah, Suparman Suparman 2015, 'BIOASSAY-GUIDED FRACTINATION OF ANTIMITOTIC COMPOUND FROM ONGKEA CORTEX (MEZZETTIAPARVIFLORA BECC) TOWARDS SEA URCHIN EGGS', Journal of Tropical Pharmacy and Chemistryhttps://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/88. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Multiple methods including surgery, radiotherapy, antimitotic agents, silicone sheet, pressure clips and cryotherapy have been advocated.
Reuben F De Sousa, Bijitesh Chakravarty, Alok Sharma, M Alam Parwaz, Anil Malik 2014, 'Efficacy of triple therapy in auricular keloids', Journal of Cutaneous and Aesthetic Surgeryhttp://www.jcasonline.com/article.asp?issn=0974-2077;year=2014;volume=7;issue=2;spage=98;epage=102;aulast=De. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The indole scaffold has been recognized as an important scaffold in the design of novel compounds acting as antimitotic agents.
Delia Preti, Romeo Romagnoli, Riccardo Rondanin, Barbara Cacciari, Ernest Hamel, JanBalzarini, Sandra Liekens, Dominique Schols, Francisco Estévez-Sarmiento, José Quintana,Francisco Estévez 2018, 'Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studiesof 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivativesobtained by a molecular hybridisation approach', Journal of Enzyme Inhibition and Medicinal Chemistryhttp://dx.doi.org/10.1080/14756366.2018.1493473. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The same allele was also significantly associated with sensitivity to antimitotic agents compared to other agents (p=0.003).
Julie eKim, Yava L Jones-Hall, Rongrong eWei, Jamie eMyers, Yuan eQi, Gregory T Knipp,Wanqing eLiu, Wanqing eLiu 2013, 'Association Between hTERT rs2736100 Polymorphism and Sensitivity to Anti-cancer Agents',Frontiers in Geneticshttp://journal.frontiersin.org/Journal/10.3389/fgene.2013.00162/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They should therefore not be used freely in alternative medicine, although their antiproliferative activity may suggest antimitotic and anticarcinogenic properties.
Erhan H Erolu, Ergin Hamzaolu, Ahmet Aksoy, Ümit Budak, Yusuf Özkul 2010, 'In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures',Biological Researchhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000200005. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)