Therefore, the use of meglumine antimoniate during pregnancy should be considered as potentially embryo-toxic.
Ahmad Khosravi, Iraj Sharifi, Hadi Tavakkoli, Amin Derakhshanfar, Ali Reza Keyhani,Zohreh Salari, Seyedeh Saedeh Mosallanejad, Mehdi Bamorovat 2018, 'Embryonic toxico-pathological effects of meglumine antimoniate using a chick embryomodel.', PLoS ONEhttp://europepmc.org/articles/PMC5969735?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The lesion relapsed following two systemic treatments with meglumine antimoniate.
Maria Inês Fernandes Pimentel, Cibele Baptista, Évelyn Figueiredo Rubin, Érica deCamargo Ferreira e Vasconcellos, Marcelo Rosandiski Lyra, Mariza de Matos Salgueiro,Maurício Naoto Saheki, Cláudia Maria Valete Rosalino, Maria de Fátima Madeira, AlineFagundes da Silva, Eliame Mouta Confort, Armando de Oliveira Schubach 2011, 'American cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis resistantto meglumine antimoniate, but with good response to pentamidine: a case report', Revista da Sociedade Brasileira de Medicina Tropicalhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000200026&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The majority of patients (74.9%) were treated with meglumine antimoniate.
Bahador Sarkari, Tahereh Naraki, Mohammad Amin Ghatee, Samaneh Abdolahi Khabisi, MohammadHassan Davami 2016, 'Visceral Leishmaniasis in Southwestern Iran: A Retrospective Clinico-HematologicalAnalysis of 380 Consecutive Hospitalized Cases (1999–2014)', PLOS ONE10.1371/journal.pone.0150406. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Treatment with meglumine antimoniate injections led to improvement.
Yavuz Yesilova, Enver Turan, Hacer Altun Sürücü, Sezen Kocarslan, Osman Tanrikulu,Naime Eroglu 2014, 'Ulcerative penile Leishmaniasis in a child', Indian Journal of Dermatology, Venereology and Leprologyhttp://www.ijdvl.com/article.asp?issn=0378-6323;year=2014;volume=80;issue=3;spage=247;epage=249;aulast=Yesilova. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Treatment commenced with meglumine antimoniate resulting in regression of the condition.
Adrilena Lopes Adriano, Paula Azevedo Borges Leal, Marcelle Parente Breckenfeld, Igordos Santos Costa, Clarisse Almeida, Antônio Renê Diógenes de Sousa 2013, 'American tegumentary leishmaniasis: an uncommon clinical and histopathological presentationLeishmaniose tegumentar americana: uma apresentação clínica e histopatológica incomum',Anais Brasileiros de Dermatologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000200260. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Meglumine antimoniate caused mild-to-moderate changes in heart and lung tissues.
Luiz Filipe Gonçalves Oliveira, Franklin Souza-Silva, Léa Cysne-Finkelstein, KíssilaRabelo, Juliana Fernandes Amorim, Adriana de Souza Azevedo, Saulo Cabral Bourguignon,Vitor Francisco Ferreira, Marciano Viana Paes, Carlos Roberto Alves 2017, 'Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with OxiranesCompared to Meglumine Antimoniate', BioMed Research Internationalhttp://dx.doi.org/10.1155/2017/9840210. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The response to treatment with compounds of meglumine antimoniate (glucantime) was better than other treatments.
Marziyeh Karami, Monir Doudi, Mahbubeh Setorki 2013, 'Assessing epidemiology of cutaneous leishmaniasis in Isfahan, Iran', Journal of Vector Borne Diseaseshttp://www.mrcindia.org/journal/issues/501030.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The patient was treated with meglumine antimoniate intramuscularly and fluconazoleorally.
Özlem Ekiz, Emine Nur Rifaioglu, Bilge Bülbül Sen, Gülnaz Çulha, Tümay Özgür, AsenaÇigdem Dogramaci 2015, 'Leishmaniasis recidiva cutis of the lips mimicking granulomatous cheilitis', Indian Journal of Dermatologyhttp://www.e-ijd.org/article.asp?issn=0019-5154;year=2015;volume=60;issue=2;spage=216;epage=216;aulast=Ekiz. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)