A high degree of selectivity of antiparasitic activity over toxicity to mammalian cells was observed.
Renata Celi Carvalho de Souza Pietra, Lucas Fonseca Rodrigues, Eliane Teixeira, LeviFried, Benjamin Lefkove, Ana Rabello, Jack Arbiser, Lucas Antônio Miranda Ferreira,Ana Paula Fernandes 2013, 'Triphenylmethane Derivatives Have High In Vitro and In Vivo Activity against the MainCausative Agents of Cutaneous Leishmaniasis', PLoS ONE10.1371/journal.pone.0051864. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Several of the tested compounds are suitable leads for the development of improved antiparasitic agents.
Jean J. Vanden Eynde, Annie Mayence, Madhusoodanan Mottamal, Cyrus J. Bacchi, NigelYarlett, Marcel Kaiser, Reto Brun, Tien L. Huang 2016, 'Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents', Pharmaceuticalshttp://www.mdpi.com/1424-8247/9/2/20. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The antiparasitic activity of all compounds was evaluated.
Olfa Chiboub, Ines Sifaoui, Jacob Lorenzo-Morales, Manef Abderrabba, Mondher Mejri,José Javier Fernández, José E. Piñero, Ana R. Díaz-Marrero 2019, 'Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis',Marine Drugshttps://www.mdpi.com/1660-3397/17/3/192. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Rotenone and its derivatives showed differential in vitro antiparasitic activity and selective cytotoxicity.
Yulieth Upegui, Juan F. Gil, Wiston Quiñones, Fernando Torres, Gustavo Escobar, SaraM. Robledo, Fernando Echeverri 2014, 'Preparation of Rotenone Derivatives and in Vitro Analysis of Their Antimalarial, Antileishmanialand Selective Cytotoxic Activities', Moleculeshttp://www.mdpi.com/1420-3049/19/11/18911. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Herbal essential oils have been proved to possess antimicrobial, antiviral, antifungal and antiparasitic properties.
Sylwia Katarzyna Król, Krystyna Skalicka-Woźniak, Martyna Kandefer-Szerszeń,Andrzej Stepulak 2013, 'The biological and pharmacological activity of essential oils in the treatment andprevention of infectious diseases', Postępy Higieny i Medycyny Doświadczalnejhttp://journals.indexcopernicus.com/fulltxt.php?ICID=1067687. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The patient was treated with nitazoxanide, a 5-nitrothiazole broad-spectrum antiparasitic agent.
Sérgio Cimerman, Maria Cecília Teixeira Ladeira, Wilma Assunção Iuliano 2003, 'Blastocistose: nitazoxanida como nova opção terapêutica Blastocystosis: nitazoxanideas a new therapeutic option', Revista da Sociedade Brasileira de Medicina Tropicalhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000300016. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It has served as an attractive target in immunosuppressive, anticancer, antiviral, and antiparasitic therapeutic strategies.
Rui-Juan Li, Ya-Li Wang, Qing-He Wang, Jian Wang, Mao-Sheng Cheng 2015, 'In Silico Design of Human IMPDH Inhibitors Using Pharmacophore Mapping and MolecularDocking Approaches', Computational and Mathematical Methods in Medicinehttp://dx.doi.org/10.1155/2015/418767. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This work supports continued evaluation of ansamycin derivatives as broad spectrum antiparasitic agents.
David Wenkert, Bernadette Ramirez, Yuehai Shen, Michael A. Kron 2010, 'In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugiamalayi', Journal of Parasitology Researchhttp://dx.doi.org/10.1155/2010/716498. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They give rise to antitumor, antiparasitic, antibacterial and antiviral bioactivities.
Javier Fernández, Laura Marín, Raquel Álvarez-Alonso, Saúl Redondo, Juan Carvajal,Germán Villamizar, Claudio J. Villar, Felipe Lombó 2014, 'Biosynthetic Modularity Rules in the Bisintercalator Family of Antitumor Compounds',Marine Drugshttp://www.mdpi.com/1660-3397/12/5/2668. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This work shows that bromotyrosines are potential antiparasitic agents.
Elkin Galeano, Alejandro Martínez, Olivier P. Thomas, Sara Robledo, Diana Munoz 2012, 'Antiparasitic bromotyrosine derivatives from the Caribbean marine sponge Aiolochroiacrassa', Química Novahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600023&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)