a sulfonamide diuretic, C14H11ClN2O4S, used in the management of hypertension
Word origin
[chlor-2 + (ph)thali(mi)d(ine) a chemical component of the drug + (ket)one]chlor- is a combining form used in the names of chemical compounds in which chlorine ispresent. Other words that use the affix chlor- include: chloral, chloride, chlormerodrin, chlorpromazine, heptachlor
Examples of 'chlorthalidone' in a sentence
chlorthalidone
The patient opted for conservative therapy with losartan, carvedilol, chlorthalidone, and atorvastatin.
Rehan Shah, Mark S. Segal, Michael J. Wilkowski 2017, 'Case Report of Spontaneous Remission of Biopsy-Proven Idiopathic Immune Complex-MediatedMembranoproliferative Glomerulonephritis', Case Reports in Nephrology and Dialysishttp://www.karger.com/Article/FullText/477660. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
After a 2-week period using placebo, patients received chlorthalidone or diltiazem for 4 weeks.
João Batista Serro-Azul, Rogério Silva de Paula, César Gruppi, Lígia Pinto, HumbertoPierri, Amit Nussbacher, Otávio Gebara, Paulo Moffa, Antônio Carlos Pereira-Barreto,Maurício Wajngarten 2001, 'Effects of chlorthalidone and diltiazem on myocardial ischemia in elderly patientswith hypertension and coronary artery disease', Arquivos Brasileiros de Cardiologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400001. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, indapamide and low dose chlorthalidone have fewer side-effects but continue to provide mortality benefit.
Sundeep Mishra 2016, 'Diuretics in primary hypertension – Reloaded', Indian Heart Journalhttp://www.sciencedirect.com/science/article/pii/S001948321630414X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The trial arms will be chlorthalidone 12.5 mg plus amiloride 2.5 mg or identical placebo.
Neto José, Pereira e Silva Ricardo, Filho Dario, Alves João, Chaves Hilton, Mota Marco,Scala Luiz, Neto Abrahão, Jardim Paulo, Ribeiro Antônio, de Sousa Marcos R, BrandãoAndréa, Franco Roberto, Cesarino Evandro, Moreno Heitor, Vilela-Martin José F, CoelhoEduardo, Nobre Fernando, Consolim-Colombo Fernanda, Bortoloto Luiz, Mion Décio, Poli-de-FigueiredoCarlos E, Nóbrega Antônio C, Gus Miguel, Moreira Leila B, Fuchs Sandra C, Fuchs FlávioD, Irigoyen Maria, Castro Iran, Steffens André, Schlatter Rosane, de Mello Renato,Mosele Francisca, Ghizzoni Flávia, Berwanger Otávio 2011, 'Prevention of hypertension in patients with pre-hypertension: protocol for the PREVER-preventiontrial', Trialshttp://www.trialsjournal.com/content/12/1/65. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Substantial degradation of chlorthalidone was obtained in acid, alkali, and oxidative conditions.
Sandeep Sonawane, Sneha Jadhav, Priya Rahade, Santosh Chhajed, Sanjay Kshirsagar 2016, 'Development and Validation of Stability-Indicating Method for Estimation of Chlorthalidonein Bulk and Tablets with the Use of Experimental Design in Forced Degradation Experiments',Scientificahttp://dx.doi.org/10.1155/2016/4286482. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The aim of this study was to compare the effect of chlorthalidone and diltiazem on myocardial ischemia.
João Batista Serro-Azul, Rogério Silva de Paula, César Gruppi, Lígia Pinto, HumbertoPierri, Amit Nussbacher, Otávio Gebara, Paulo Moffa, Antônio Carlos Pereira-Barreto,Maurício Wajngarten 2001, 'Effects of chlorthalidone and diltiazem on myocardial ischemia in elderly patientswith hypertension and coronary artery disease', Arquivos Brasileiros de Cardiologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2001000400001. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)