Only sucralose intake increased the concentration of hepatic cholesterol and cholic acid.
Takashi Uebanso, Ai Ohnishi, Reiko Kitayama, Ayumi Yoshimoto, Mutsumi Nakahashi, TakaakiShimohata, Kazuaki Mawatari, Akira Takahashi 2017, 'Effects of Low-Dose Non-Caloric Sweetener Consumption on Gut Microbiota in Mice',Nutrientshttp://www.mdpi.com/2072-6643/9/6/560. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Other species, such as the cholic, hyocholic and hyodeoxycholic acids were nontoxic.
Martin Perreault, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron,Piotr Milkiewicz, Olivier Barbier 2013, 'Role of glucuronidation for hepatic detoxification and urinary elimination of toxicbile acids during biliary obstruction.', PLoS ONEhttp://europepmc.org/articles/PMC3828276?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The lithogenic properties of bile are primarily caused by conjugated forms of cholic acid with glycine and taurine content violation.
V. M. Klymenko, D. V. Syvolap, A. G. Kaplaushenko, B. O. Varynskyi 2017, 'The composition of bile acids in patients with cholelithiasis according to the dataof liquid chromatography with mass spectrometric detection', Zaporožskij Medicinskij Žurnalhttp://zmj.zsmu.edu.ua/article/view/114710/113460. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)