an endeavour to readjust the body clock to enable a person to waken earlier by going to sleep later and later every day until the required waking hour is achieved
chronotherapy in American English
(ˌkrɑnəˈθerəpi, ˌkrounə-)
noun
Medicine
a treatment for insomnia in which a person's normal cycle of waking and sleeping is altered
Word origin
[1975–80; chrono- + therapy]This word is first recorded in the period 1975–80. Other words that entered Englishat around the same time include: bench press, family therapy, gravitational lens, methanogen, videotexchrono- is a combining form meaning “time,” used in the formation of compound words. Otherwords that use the affix chrono- include: chronograph, chronometer, chronopher, chronoscope, chronotropic
Examples of 'chronotherapy' in a sentence
chronotherapy
In this review, we will focus on mammalian circadian pharmacodynamics and discuss new chronotherapy approaches.
Pinar Erkekoglu, Terken Baydar 2012, 'Chronopharmacodynamics of drugs in toxicological aspects: A short review for clinicalpharmacists and pharmacy practitioners', Journal of Research in Pharmacy Practicehttp://www.jrpp.net/article.asp?issn=2319-9644;year=2012;volume=1;issue=2;spage=41;epage=47;aulast=Erkekoglu. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Targeted therapies as well as chronotherapy were trialled with more or less success.
Loredana G. Marcu 2013, 'Improving Therapeutic Ratio in Head and Neck Cancer with Adjuvant and Cisplatin-BasedTreatments', BioMed Research Internationalhttp://dx.doi.org/10.1155/2013/817279. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The knowledge on the circadian clock led to the development of chronopharmacologyand chronotherapy.
Klara Janjić, Hermann Agis 2019, 'Chronodentistry: the role & potential of molecular clocks in oral medicine', BMC Oral Healthhttp://link.springer.com/article/10.1186/s12903-019-0720-x. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This may be particularly useful in examining chronotherapy effects of antihypertensive medication.
Jamie M. Madden, Xia Li, Patricia M. Kearney, Kate Tilling, Anthony P. Fitzgerald 2017, 'Exploring diurnal variation using piecewise linear splines: an example using bloodpressure', Emerging Themes in Epidemiologyhttp://link.springer.com/article/10.1186/s12982-017-0055-5. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both gene sets can be used for patient stratification in adjuvant chronotherapy treatment.
Wai Hoong Chang, Alvina G. Lai 2019, 'Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadianclock and crosstalk with hypoxia signalling in diverse malignancies', Journal of Translational Medicinehttp://link.springer.com/article/10.1186/s12967-019-1880-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Differential expression of circadian genes in non-cancerous and cancerous cells may provide amolecular basis for chronotherapy of glioma.
Wang Fan, Xiaowei Chen, Caiyan Li, Yongluo, Lvan Chen, Pingfei Liu, Zhijun Chen 2014, 'The analysis of deregulated expression and methylation of the PER2 genes in gliomas',Journal of Cancer Research and Therapeuticshttp://www.cancerjournal.net/article.asp?issn=0973-1482;year=2014;volume=10;issue=3;spage=636;epage=640;aulast=Fan. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The authors obtained impressive results – more than a double reduction of cardiovascular complications risk in the chronotherapy group.
V. M. Gorbunov, E. Y. Fedorova, E. V. Platonova 2017, 'CHRONOTHERAPY OF HYPERTENSION: CURRENT STATE OF THE SCIENTIFIC PROBLEM', Racionalʹnaâ Farmakoterapiâ v Kardiologiihttps://www.rpcardio.com/jour/article/view/1539. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Review devoted to chronotherapy of hypertension.
O. V. Petrenko 2015, 'CHRONOTHERAPY OF HYPERTENSION: LITERATURE REVIEW', Journal of V. N. Karazin Kharkiv National University: Series Medicinehttp://periodicals.karazin.ua/medicine/article/view/3738/3305. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These derivatives could be useful as a chronotherapy for rheumatoid arthritis due to their prolonged analgesic and anti-inflammatory effects.
Suneela Dhaneshwar, Anuradha Sutar, Parag Kadam 2016, 'Reducing ulcerogenic potential of biphenyl acetic acid: Design and development ofchimeric derivatives with amino acids', Journal of Saudi Chemical Societyhttp://www.sciencedirect.com/science/article/pii/S1319610312001597. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)