a substance that counteracts the action of thrombin, preventing the formation of blood clots
Examples of 'antithrombin' in a sentence
antithrombin
A supraphysiological substitution of blood with antithrombin significantly reduces platelet adhesion rate.
Scharf Rüdiger E, Thomas Volker, Stoldt Volker, Kalina Uwe, Loncar Robert, VodovnikAleksandar 2006, 'Antithrombin significantly influences platelet adhesion onto immobilized fibrinogenin an in-vitro system simulating low flow', Thrombosis Journalhttp://www.thrombosisjournal.com/content/4/1/19. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Three cases with moderate antithrombin deficiency (63-78%) carried potential regulatory mutations.
Mara Toderici, María Eugenia de la Morena-Barrio, José Padilla, Antonia Miñano, AnaIsabel Antón, Juan Antonio Iniesta, María Teresa Herranz, Nuria Fernández, VicenteVicente, Javier Corral 2016, 'Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response ElementsAssociated with Antithrombin Deficiency.', PLoS ONEhttp://europepmc.org/articles/PMC4803246?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thus, the concomitant use of antithrombin concentrate and recombinant thrombomodulin has been conceived.
Toshiaki Iba, Akiyoshi Hagiwara, Daizoh Saitoh, Hideaki Anan, Yutaka Ueki, KoichiSato, Satoshi Gando 2017, 'Effects of combination therapy using antithrombin and thrombomodulin for sepsis-associateddisseminated intravascular coagulation', Annals of Intensive Carehttp://link.springer.com/article/10.1186/s13613-017-0332-z. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The distribution of positive charges shows considerable asymmetry in antithrombin, but substantial symmetry for thrombin.
Philip D Mosier, Chandravel Krishnasamy, Glen E Kellogg, Umesh R Desai 2012, 'On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding siteson antithrombin and thrombin are fundamentally different.', PLoS ONEhttp://europepmc.org/articles/PMC3495972?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Indomethacin was discontinued, and the patient was started on fondaparinux and antithrombin.
Mantarro Stefania, Tuccori Marco, Pasqualetti Giuseppe, Tognini Sara, Montagnani Sabrina,Monzani Fabio, Blandizzi Corrado 2012, 'Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderlypatient', BMC Geriatricshttp://www.biomedcentral.com/1471-2318/12/69. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Bound thrombin was detected immunoenzymatically using a peroxidase-linked antithrombin antibody and a chromogenic substrate.
Sally Smiley, Maria DeRosa, Burton Blais 2013, 'Immobilization of DNA Aptamers on Polyester Cloth for Antigen Detection by Dot BlotImmunoenzymatic Assay (Aptablot)', Journal of Nucleic Acidshttp://dx.doi.org/10.1155/2013/936542. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Three cases with moderate antithrombin deficiency (63–78%) carried potential regulatorymutations.
Mara Toderici, María Eugenia de la Morena-Barrio, José Padilla, Antonia Miñano, AnaIsabel Antón, Juan Antonio Iniesta, María Teresa Herranz, Nuria Fernández, VicenteVicente, Javier Corral 2016, 'Identification of Regulatory Mutations in SERPINC1 Affecting Vitamin D Response ElementsAssociated with Antithrombin Deficiency', PLOS ONE10.1371/journal.pone.0152159. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Prospective randomized trials are needed to determine the optimal antithrombin strategy for preventing this common and serious adverse outcome.
Jacob A Udell, Julie T Wang, David J Gladstone, Jack V Tu 2010, 'Anticoagulation after anterior myocardial infarction and the risk of stroke.', PLoS ONEhttp://europepmc.org/articles/PMC2921337?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We investigated the relationship between antithrombin levels and organ failure as well as mortality in pediatric patients with sepsis.
Christian Niederwanger, Tobias Hell, Sophie Hofer, Christina Salvador, Miriam Michel,Bettina Schenk, Benedikt Treml, Mirjam Bachler 2018, 'Antithrombin deficiency is associated with mortality and impaired organ function inseptic pediatric patients: a retrospective study', PeerJhttps://peerj.com/articles/5538.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antithrombin could be useful as a prognostic marker for survival and occurrence of organ failure in pediatric sepsis.
Christian Niederwanger, Tobias Hell, Sophie Hofer, Christina Salvador, Miriam Michel,Bettina Schenk, Benedikt Treml, Mirjam Bachler 2018, 'Antithrombin deficiency is associated with mortality and impaired organ function inseptic pediatric patients: a retrospective study', PeerJhttps://peerj.com/articles/5538.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)