All clinical signs and metabolic abnormalities, except proteinuria, were reversed by regular parenteral cobalamin administration.
John C. Fyfe, Shelby L. Hemker, Alycia Frampton, Karthik Raj, Peter L. Nagy, KristiJ. Gibbon, Urs Giger 2018, 'Inherited selective cobalamin malabsorption in Komondor dogs associated with a CUBNsplice site variant', BMC Veterinary Researchhttp://link.springer.com/article/10.1186/s12917-018-1752-1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this study, we saw that most common of pancytopenia was cause of cobalamin deficiency.
Vijayashree Thyagaraj, Ashwin Kulkarni, Anil Kumar T, Ashwini N. G 2017, 'THE STUDY OF CLINICO-AETIOLOGICAL PROFILE OF PANCYTOPENIA IN ELDERLY POPULATION',Journal of Evidence Based Medicine and Healthcarehttp://www.jebmh.com/data_pdf/Ashwini%20Kulkarni%20-%20FINAL.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Since mammals cannot synthesize cobalamin, dietary intake represents the only natural source for humans.
Adele Repossi, Elisa Zironi, Teresa Gazzotti, Andrea Serraino, Giampiero Pagliuca 2017, 'Vitamin B12 determination in milk, whey and different by-products of ricotta cheeseproduction by ultra performance liquid chromatography coupled with tandem mass spectrometry',Italian Journal of Food Safetyhttp://www.pagepressjournals.org/index.php/ijfs/article/view/6795. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cobalamin and folate deficiencies play an important role in the etiology of anemia.
Umesh Kapil, GS Toteja, Ajeet Singh Bhadoria 2015, 'Cobalamin and folate deficiencies among children in the age group of 12-59 monthsin India', Biomedical Journalhttp://www.biomedj.org/article.asp?issn=2319-4170;year=2015;volume=38;issue=2;spage=162;epage=166;aulast=Kapil. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The findings were low cobalamin and folate levels, and high homocysteine and methylmalonate levels.
Chapuis Thomas M, Favrat Bernard, Bodenmann Patrick 2009, 'Cobalamin deficiency resulting in a rare haematological disorder: a case report',Journal of Medical Case Reportshttp://www.jmedicalcasereports.com/content/3/1/80. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption.
Emmanuel Andrès, Thomas Vogel, Laure Federici, Jacques Zimmer, Ecaterina Ciobanu,Georges Kaltenbach 2008, 'Cobalamin Deficiency in Elderly Patients: A Personal View', Current Gerontology and Geriatrics Researchhttp://dx.doi.org/10.1155/2008/848267. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The patient was treated conservatively with cobalamin and aspirin and advised for revascularization.
Durga Shankar Meena, Gopal Krishana Bohra, Mahadev Meena, Bharat Kumar Maheshwari 2018, 'Hyperhomocysteinemia in a Patient with Moyamoya Disease', Case Reports in Neurological Medicinehttp://dx.doi.org/10.1155/2018/7806873. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Instead, the non-functional part of circulating cobalamin bound to haptocorrin declined (p = 0.0009).
Ebba Nexo, Finn F. Lauszus, Mustafa V. Bor, Birgitta Trolle, Eva Greibe 2013, 'Metformin Lowers Serum Cobalamin without Changing Other Markers of Cobalamin Status:A Study on Women with Polycystic Ovary Syndrome', Nutrientshttp://www.mdpi.com/2072-6643/5/7/2475. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our results indicated a high prevalence of nutritional cobalamin deficiency, whilefolate deficiency was uncommon.
Ram K. Chandyo, Manjeswori Ulak, Halvor Sommerfelt, Jørn Schneede, Per M. Ueland,Tor A. Strand 2016, 'Nutritional Intake and Status of Cobalamin and Folate among Non-Pregnant Women ofReproductive Age in Bhaktapur, Nepal', Nutrientshttp://www.mdpi.com/2072-6643/8/6/375. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These include clusters directing, the production of hydrogenases, tetrathionate respiration, cobalamin synthesis, and propanediol utilisation.
Nicholas R Thomson, Sarah Howard, Brendan W Wren, Matthew T G Holden, Lisa Crossman,Gregory L Challis, Carol Churcher, Karen Mungall, Karen Brooks, Tracey Chillingworth,Theresa Feltwell, Zahra Abdellah, Heidi Hauser, Kay Jagels, Mark Maddison, SharonMoule, Mandy Sanders, Sally Whitehead, Michael A Quail, Gordon Dougan, Julian Parkhill,Michael B Prentice 2006, 'The complete genome sequence and comparative genome analysis of the high pathogenicityYersinia enterocolitica strain 8081.', PLoS Geneticshttp://europepmc.org/articles/PMC1698947?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)