a drug, C13H18Cl2N2O2, used to treat myeloid leukaemia
Examples of 'melphalan' in a sentence
melphalan
Twenty eyes (16 patients) underwent 40 intra-arterial melphalan infusions, and dose was determined by age.
Thampi S, Hetts SW, Cooke DL, Stewart PJ, Robbins E, Banerjee A, DuBois SG, Char D,Halbach V, Matthay K 2013, 'Superselective intra-arterial melphalan therapy for newly diagnosed and refractoryretinoblastoma: results from a single institution', Clinical Ophthalmologyhttp://www.dovepress.com/superselective-intra-arterial-melphalan-therapy-for-newly-diagnosed-an-a13156. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Corticosteroids and melphalan were used for decades to treat multiple myeloma.
Amir Harandi, Damian A. Laber 2011, 'Historical perspective and advances in the treatment of multiple myeloma', Oncology Reviewshttp://www.oncologyreviews.org/index.php/or/article/view/133. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Combination chemotherapy has been extensively studied with similar overall survival rates to melphalan and prednisone.
Amir Harandi, Damian A. Laber 2011, 'Historical perspective and advances in the treatment of multiple myeloma', Oncology Reviewshttp://www.oncologyreviews.org/index.php/or/article/view/133. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The response to therapy with melphalan and prednisolono had been quite encouraging.
Inderjeet Kaur, Bhushan Kumar, Arvind Rajwanshi, Surrinder Kaur 1983, 'Primary Systemic Amiyloidosis with Bullous Lesions', Indian Journal of Dermatology, Venereology and Leprologyhttp://www.ijdvl.com/article.asp?issn=0378-6323;year=1983;volume=49;issue=1;spage=29;epage=33;aulast=Kaur;type=0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our case eventually received autologous hematopoietic stem cell transplantation with high dose melphalan.
Panitha Jindahra, Charungthai Dejthevaporn, Pimjai Niparuck, Jariya Waisayarat, PiyaphonCheecharoen, Thanatporn Threetong, Purit Petpiroon, Tharikarn Sujirakul, Anuchit Poonyathalang,Kavin Vanikieti 2018, 'Atypical central retinal artery occlusion as the first presentation of POEMS syndrome:a case report', BMC Neurologyhttp://link.springer.com/article/10.1186/s12883-018-1071-y. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Consequently, the generation of predictive signatures for response to melphalan may have a clinical impact.
Martin Boegsted, Johanne M Holst, Kirsten Fogd, Steffen Falgreen, Suzette Sørensen,Alexander Schmitz, Anne Bukh, Hans E Johnsen, Mette Nyegaard, Karen Dybkaer 2011, 'Generation of a predictive melphalan resistance index by drug screen of B-cell cancercell lines.', PLoS ONEhttp://europepmc.org/articles/PMC3084810?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Treatment regimens based on melphalan and farmorubicin were used less frequently.
Mateja Grat, Sokolovič Ivana, Joško Vučković, Tadeja Jelenko, Albina Rezar Planko 2012, 'Treatment of multiple myeloma in Celje general hospital in the five-year period from2007–2011', Zdravniški Vestnikhttp://vestnik.szd.si/index.php/ZdravVest/article/view/775. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Melphalan hypoxic pelvic perfusion may, therefore, be an option for these non-responsive patients.
Stefano Guadagni, Giammaria Fiorentini, Marco Clementi, Giancarlo Palumbo, Paola Palumbo,Alessandro Chiominto, Stefano Baldoni, Francesco Masedu, Marco Valenti, Ambra Di Tommaso,Bianca Fabi, Camillo Aliberti, Donatella Sarti, Veronica Guadagni, Cristina Pellegrini 2017, 'Does Locoregional Chemotherapy Still Matter in the Treatment of Advanced Pelvic Melanoma?',International Journal of Molecular Scienceshttps://www.mdpi.com/1422-0067/18/11/2382. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Treatment included melphalan and autologous stem cell transplant.
Peter Kalina, Jeffrey B. Rykken 2012, 'Multiple Myeloma of the Thyroid Cartilage', Case Reports in Hematologyhttp://dx.doi.org/10.1155/2012/194797. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)