(of inbred animal cells) genetically identical except for a single gene locus
Examples of 'congenic' in a sentence
congenic
Thus, three congenic strains were established through rapid generation turnover between 41 and 44 days.
Narumi Ogonuki, Kimiko Inoue, Michiko Hirose, Ikuo Miura, Keiji Mochida, TakahiroSato, Nathan Mise, Kazuyuki Mekada, Atsushi Yoshiki, Kuniya Abe, Hiroki Kurihara,Shigeharu Wakana, Atsuo Ogura 2009, 'A high-speed congenic strategy using first-wave male germ cells.', PLoS ONEhttp://europepmc.org/articles/PMC2659429?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We established a congenic strain to validate the effect of this region on disease.
Pernilla Stridh, Melanie Thessen Hedreul, Amennai Daniel Beyeen, Milena Z Adzemovic,Hannes Laaksonen, Alan Gillett, Johan Ockinger, Monica Marta, Hans Lassmann, KristinaBecanovic, Maja Jagodic, Tomas Olsson 2010, 'Fine-mapping resolves Eae23 into two QTLs and implicates ZEB1 as a candidate generegulating experimental neuroinflammation in rat.', PLoS ONEhttp://europepmc.org/articles/PMC2939884?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The congenic strain had 1.59 fold higher renal expression of rififylin.
Bina eJoe, Kathirvel eGopalakrishnan, Sivarajan eKumarasamy, Yanling eYan, Jiang eLiu,Andrea L Kalinoski, Anbarasi eKodandapani, Phyllis eFarms 2012, 'Increased expression of Rififylin in a <330kb congenic strain is linked to impairedendosomal recycling in proximal tubules', Frontiers in Geneticshttp://journal.frontiersin.org/Journal/10.3389/fgene.2012.00138/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Results show that genes in the congenic donor regions were preferentially selected.
Warden Craig H, Farber Charles R, Verdugo Ricardo A, Medrano Juan F 2010, 'Serious limitations of the QTL/Microarray approach for QTL gene discovery', BMC Biologyhttp://www.biomedcentral.com/1741-7007/8/96. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, their utility depends on the maintenance of this true congenic nature.
Wilkinson Maureen, Richardson Kelly S, Nibley Megan, Ma Maggie S, Groesbeck Zack J,Gardner Kyle, Damjanovich Kristy, McClelland Erin E, Morrison Linda C, Bernhardt Paul,Potts Wayne K 2004, 'Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: can we trustcongenic animals?', BMC Immunologyhttp://www.biomedcentral.com/1471-2172/5/14. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Transcriptomic analysis confirmed that the chemical carcinogenesis pathway was significantly up-regulated in the congenic strain.
Xi Cheng, Harshal Waghulde, Blair Mell, Kathryn Smedlund, Guillermo Vazquez, BinaJoe 2016, 'Pleiotropic Effect of a High Resolution Mapped Blood Pressure QTL on Tumorigenesis',PLOS ONE10.1371/journal.pone.0153519. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this report, we describe a combination of congenic mapping and allele-specific alteration analysis of the loci on chromosome 7.
Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Ikuo Miura, Shigeharu Wakana, Ryo Kominami,Yuichi Wakabayashi 2014, 'Congenic Mapping and Allele-Specific Alteration Analysis of Stmm1 Locus ConferringResistance to Early-Stage Chemically Induced Skin Papillomas', PLoS ONE10.1371/journal.pone.0097201. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
To that end, we analyzed the weight of the gonadal adipose depot from newly created congenic strains.
Cailu Lin, Brad D Fesi, Michael Marquis, Natalia P Bosak, Anna Lysenko, Mohammed AminKoshnevisan, Fujiko F Duke, Maria L Theodorides, Theodore M Nelson, Amanda H McDaniel,Mauricio Avigdor, Charles J Arayata, Lauren Shaw, Alexander A Bachmanov, DanielleR Reed 2017, 'Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenicstrains.', PLoS ONEhttp://europepmc.org/articles/PMC5711020?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both congenic strains were relatively resistant to spontaneous arthritis and had delayed onset and reduced severity of disease.
Yanhong Cao, Xiaoyun Liu, Nan Deng, Yan Jiao, Yonghui Ma, Karen A. Hasty, John M.Stuart, Weikuan Gu 2013, 'Congenic Mice Provide Evidence for a Genetic Locus That Modulates Spontaneous ArthritisCaused by Deficiency of IL-1RA', PLoS ONE10.1371/journal.pone.0068158. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Transcriptome analysis indicated that components of both endocytosis and recycling were upregulated in the congenic strain.
Bina eJoe, Kathirvel eGopalakrishnan, Sivarajan eKumarasamy, Yanling eYan, Jiang eLiu,Andrea L Kalinoski, Anbarasi eKodandapani, Phyllis eFarms 2012, 'Increased expression of Rififylin in a <330kb congenic strain is linked to impairedendosomal recycling in proximal tubules', Frontiers in Geneticshttp://journal.frontiersin.org/Journal/10.3389/fgene.2012.00138/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)