Immunohistochemistry was used to observe the microtubular cytoskeleton of the cultured cells.
Cui-cui Yang, Xue-xian Kuai, Ya-li Li, Li Zhang, Jian-chun Yu, Lin Li, Lan Zhang 2013, 'Cornel Iridoid Glycoside Attenuates Tau Hyperphosphorylation by Inhibition of PP2ADemethylation', Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1155/2013/108486. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the signaling pathways involved in hypoxia-induced microtubular disruption are unknown.
Huaming Cao, Dongsheng Yu, Xueyun Yan, Bing Wang, Zhiming Yu, Yu Song, Liang Sheng 2019, 'Hypoxia destroys the microstructure of microtubules and causes dysfunction of endothelialcells via the PI3K/Stathmin1 pathway', Cell & Biosciencehttp://link.springer.com/article/10.1186/s13578-019-0283-1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Disruption of the microtubular network has been reported in cases of ischemia.
Huaming Cao, Dongsheng Yu, Xueyun Yan, Bing Wang, Zhiming Yu, Yu Song, Liang Sheng 2019, 'Hypoxia destroys the microstructure of microtubules and causes dysfunction of endothelialcells via the PI3K/Stathmin1 pathway', Cell & Biosciencehttp://link.springer.com/article/10.1186/s13578-019-0283-1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Infection of non-enveloped polyomaviruses depends on an intact microtubular network.
Vojtech Zila, Francesco Difato, Lucie Klimova, Sandra Huerfano, Jitka Forstova 2014, 'Involvement of microtubular network and its motors in productive endocytic traffickingof mouse polyomavirus.', PLoS ONEhttp://europepmc.org/articles/PMC4014599?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The microtubular cytoskeleton was visualized in the nuclear, alveolar and cellular endosperm.
A. A.M. van Lammeren, H. Kieft, F. Ma, L. H. van Veenendaal 2014, 'Light microscopical study of endosperm formation in Brassica napus L.', Acta Societatis Botanicorum Poloniaehttps://pbsociety.org.pl/journals/index.php/asbp/article/view/941. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Endosomes offer a convenient and often rapid transit system across the plasma membrane and cytoplasm via the cellular microtubular network.
Anna Słońska, Joanna Cymerys, Marcin W. Bańbura 2016, 'Mechanisms of endocytosis utilized by viruses during infection', Postępy Higieny i Medycyny Doświadczalnejhttp://phmd.pl/gicid/01.3001.0009.6837. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The intriguing properties of self-assembled microtubular architectures open new possibilities to develop three-dimensional functional devices for molecule and cell analysis.
Mariana Medina-Sánchez, Sonja M. Weiz, Aleksandr Egunov, Bergoi Ibarlucea, LarysaBaraban, Gianaurelio Cuniberti, Oliver G. Schmidt 2017, 'Lab-In-A-Tube: From Molecule to Cell Detection', Proceedingshttps://www.mdpi.com/2504-3900/1/8/840. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Therefore, we hypothesized that this process was dependent on the cellular microtubular network and its associated dynamic components.
Catherine Eichwald, Francesca Arnoldi, Andrea S Laimbacher, Elisabeth M Schraner,Cornel Fraefel, Peter Wild, Oscar R Burrone, Mathias Ackermann 2012, 'Rotavirus viroplasm fusion and perinuclear localization are dynamic processes requiringstabilized microtubules.', PLoS ONEhttp://europepmc.org/articles/PMC3479128?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)