an enzyme found in organisms from bacteria to mammals but absent in humans
Examples of 'uricase' in a sentence
uricase
The serum uric acid levels were measured by the uricase method.
Kim Tae, Lee Seong, Yoo Ji, Kim Sung, Yoo Soon, Song Ho, Kim Yong-Soo, Choi Euy, KimYong Kyun 2012, 'The relationship between the regional abdominal adipose tissue distribution and theserum uric acid levels in people with type 2 diabetes mellitus', Diabetology & Metabolic Syndromehttp://www.dmsjournal.com/content/4/1/3. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Optimum uricase production with these factors was deduced using central composite design.
Sneha O. Pustake, Prashant K. Bhagwat, Padma B. Dandge 2019, 'Statistical media optimization for the production of clinical uricase from Bacillussubtilis strain SP6', Heliyonhttp://www.sciencedirect.com/science/article/pii/S2405844019322510. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Treatment for severe gout includes injection of non-human uricase to reduce serum uric acid levels.
Andrew C Nyborg, Chris Ward, Anna Zacco, Benoy Chacko, Luba Grinberg, James C Geoghegan,Ryan Bean, Michaela Wendeler, Frank Bartnik, Ellen O'Connor, Flaviu Gruia, VidyashankaraIyer, Hui Feng, Varnika Roy, Mark Berge, Jeffrey N Miner, David M Wilson, DongmeiZhou, Simone Nicholson, Clynn Wilker, Chi Y Wu, Susan Wilson, Lutz Jermutus, HerrenWu, David A Owen, Jane Osbourn, Steven Coats, Manuel Baca 2016, 'A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties.',PLoS ONEhttp://europepmc.org/articles/PMC5176304?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Nineteen strains of microorganisms were screened for uricase production.
Atalla, M. M., Farag, M. M., Eman, R. H., Abd-El-Lataif, M. S., Nehad, E. A. 2009, 'Optimum Conditions for Uricase Enzyme Production by Gliomastix gueg', Malaysian Journal of Microbiologyhttp://web.usm.my/mjm/issues/vol5no1/research8.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Biomass and uricase production at different stages of microbial growth curve for theuricase producing microbe was studied.
Harinath Dwivedi, Kusum Agrawal, Shubhini A Saraf 2012, 'Evaluation of Factors Affecting Uricase Production by the Screened Wild/Natural Microbes',E-Journal of Chemistryhttp://dx.doi.org/10.1155/2012/976242. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
More than 200 diverse uricase sequences were aligned to guide protein engineering and reduce putative sequence liabilities.
Andrew C Nyborg, Chris Ward, Anna Zacco, Benoy Chacko, Luba Grinberg, James C Geoghegan,Ryan Bean, Michaela Wendeler, Frank Bartnik, Ellen O'Connor, Flaviu Gruia, VidyashankaraIyer, Hui Feng, Varnika Roy, Mark Berge, Jeffrey N Miner, David M Wilson, DongmeiZhou, Simone Nicholson, Clynn Wilker, Chi Y Wu, Susan Wilson, Lutz Jermutus, HerrenWu, David A Owen, Jane Osbourn, Steven Coats, Manuel Baca 2016, 'A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties.',PLoS ONEhttp://europepmc.org/articles/PMC5176304?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This was achieved by utilizing the fact that uric acid dissolves on being acted upon by uricase.
Harinath Dwivedi, Kusum Agrawal, Shubhini A Saraf 2012, 'Evaluation of Factors Affecting Uricase Production by the Screened Wild/Natural Microbes',E-Journal of Chemistryhttp://dx.doi.org/10.1155/2012/976242. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)