the process of producing a horn or horny substance
cornification in American English
(ˌkɔrnəfɪˈkeiʃən)
noun
Biology
the formation of a horny layer of skin, or horny skin structures, as hair, nails, or scales, from squamous epithelial cells
Word origin
[1835–45; corn2 + -i- + -fication]This word is first recorded in the period 1835–45. Other words that entered Englishat around the same time include: communism, daisy chain, hot plate, hybridize, protein-i- is the typical ending of the first element of compounds of Latin words, as -o- is of Greek words, but often used in English with a first element of any origin,if the second element is of Latin origin. Other words that use the affix -i- include: Frenchify, cuneiform; -fication is a combining form of nouns of action or state corresponding to verbs ending in-fy. Other words that use the affix -fication include: deification, pacification
Examples of 'cornification' in a sentence
cornification
Ichthyoses are a group of various different types of hereditary disorders affecting skin cornification.
Julia Metzger, Anne Wöhlke, Reinhard Mischke, Annalena Hoffmann, Marion Hewicker-Trautwein,Eva-Maria Küch, Hassan Y. Naim, Ottmar Distl 2015, 'A Novel SLC27A4 Splice Acceptor Site Mutation in Great Danes with Ichthyosis', PLOS ONE10.1371/journal.pone.0141514. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hyperpigmentation grade and acanthosis or cornification disorders correlated positively in 88.5% of the cases.
Marjam Jeanette Barysch, Ralph Peter Braun, Isabel Kolm, Verena Ahlgrimm-Siesz, RainerHofmann-Wellenhof, Christine Duval, Emilie Warrick, Francoise Bernerd, Stéphanie Nouveau,Reinhard Dummer 2019, 'Keratinocytic Malfunction as a Trigger for the Development of Solar Lentigines', Dermatopathologyhttps://www.karger.com/Article/FullText/495404. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This condition takes place as a result of the epidermal cornification disorder.
Ahmad Farhat, Shadi Noorizadeh, Ashraf Mohamadzadeh, Reza Saeedi 2017, 'A Rare Case Report of a Collodion Baby with Severe Hypernatremia', Iranian Journal of Neonatologyhttp://ijn.mums.ac.ir/article_8921_8b988f7a1b67a14ff8794a54816b463e.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pharmacological disruption targeting actin networks resulted in granule disintegration and accelerated cornification.
Danuta Gutowska-Owsiak, Jorge Bernardino de La Serna, Marco Fritzsche, Aishath Naeem,Ewa I. Podobas, Michael Leeming, Huw Colin-York, Ryan O'Shaughnessy, Christian Eggeling,Graham S. Ogg 2018, 'Orchestrated control of filaggrin–actin scaffolds underpins cornification', Cell Death and Diseasehttp://link.springer.com/article/10.1038/s41419-018-0407-2. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cornification and epidermal barrier defects are associated with a number of clinically diverse skin disorders.
Anastasia Petrova, Anna Celli, Laureen Jacquet, Dimitra Dafou, Debra Crumrine, MelanieHupe, Matthew Arno, Carl Hobbs, Aleksandra Cvoro, Panagiotis Karagiannis, Liani Devito,Richard Sun, Lillian C. Adame, Robert Vaughan, John A. McGrath, Theodora M. Mauro,Dusko Ilic 2014, '3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human EmbryonicStem Cells and Induced Pluripotent Stem Cells', Stem Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2213671114000885. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Alterations in the epidermal cornification process affect the formation of the skin barrier.
Jens Malte Baron, Kai H. Hänel, Christian Cornelissen, Bernhard Lüscher 2013, 'Cytokines and the Skin Barrier', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/14/4/6720. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Many of the cytokines found in defective skin are able to influence various processes of differentiation and cornification.
Jens Malte Baron, Kai H. Hänel, Christian Cornelissen, Bernhard Lüscher 2013, 'Cytokines and the Skin Barrier', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/14/4/6720. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The hair of all mammals consists of terminally differentiated cells that undergo a specialized form of apoptosis called cornification.
Gloria K. Lefkowitz, Anandaroop Mukhopadhyay, Christopher Cowing-Zitron, BenjaminD. Yu 2011, 'The Post-Apoptotic Fate of RNAs Identified Through High-Throughput Sequencing of HumanHair', PLoS ONE10.1371/journal.pone.0027603. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A significant correlation of p53 and acanthosis (p = 0.003) and cornification grade (p = 0.0008) was observed.
Marjam Jeanette Barysch, Ralph Peter Braun, Isabel Kolm, Verena Ahlgrimm-Siesz, RainerHofmann-Wellenhof, Christine Duval, Emilie Warrick, Francoise Bernerd, Stéphanie Nouveau,Reinhard Dummer 2019, 'Keratinocytic Malfunction as a Trigger for the Development of Solar Lentigines', Dermatopathologyhttps://www.karger.com/Article/FullText/495404. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pathway enrichment showed the expected downregulation of melanogenic pathway and a significant downregulation of cornificationand keratinocyte differentiation processes.
Archana Singh, Vishvabandhu Gotherwal, Päivi Junni, Vinaya Vijayan, Manisha Tiwari,Parul Ganju, Avinash Kumar, Pankaj Sharma, Tanveer Fatima, Aayush Gupta, AnanthaprasadHolla, Hemanta K. Kar, Sangeeta Khanna, Lipi Thukral, Garima Malik, KrishnamurthyNatarajan, Chetan J. Gadgil, Riitta Lahesmaa, Vivek T. Natarajan, Rajni Rani, RajeshS. Gokhale 2017, 'Mapping architectural and transcriptional alterations in non-lesional and lesionalepidermis in vitiligo', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-017-10253-w. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)