a city in N central New Mexico, capital of the state: one of the oldest European settlements in North America, founded in 1610 as the capital of the Kingdom of New Mexico; developed trade with the US by the Santa Fe Trail in the early 19th century. Pop: 66 476 (2003 est)
2. (Spanish ˈsanta ˈfe)
an inland port in E Argentina, on the Salado River: University of the Littoral (1920). Pop: 492 000 (2005 est)