Vagally derived acetylcholine also regulates mucus production in the airways.
Zaagsma Johan, Gosens Reinoud, Meurs Herman, Halayko Andrew J 2006, 'Muscarinic receptor signaling in the pathophysiology of asthma and COPD', Respiratory Researchhttp://respiratory-research.com/content/7/1/73. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This could open the door to novel treatments for numerous vagally mediated diseases characterized by poor responses to current therapies.
Ryan Marshall, Ian Taylor, Christopher Lahr, Thomas L. Abell, Ingrid Espinoza, NitinK. Gupta, Christian R. Gomez 2015, 'Bioelectrical Stimulation for the Reduction of Inflammation in Inflammatory BowelDisease', Clinical Medicine Insights: Gastroenterologyhttps://doi.org/10.4137/CGast.S31779. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The literature review suggests two possible explanations: a vagally mediated response or a mechanism dependent on conduction system ischemia.
Rhanderson Cardoso, Carlos E. Alfonso, James O. Coffey 2016, 'Reversibility of High-Grade Atrioventricular Block with Revascularization in CoronaryArtery Disease without Infarction: A Literature Review', Case Reports in Cardiologyhttp://dx.doi.org/10.1155/2016/1971803. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Those vagally regulated obesogenic signals also contribute to the fat mass gain following chronic high-fat diet feeding.
Jenna Holland, Joyce Sorrell, Emily Yates, Kathleen Smith, Shahriar Arbabi, MyrthaArnold, Marita Rivir, Rachel Morano, Jenny Chen, Xiang Zhang, Richard Dimarchi, StephenC. Woods, Joan Sanchez-Gurmaches, Eric Wohleb, Diego Perez-Tilve 2019, 'A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently ofEnergy Intake', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124719305698. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Primarily used as bronchodilators, they reverse the action of vagally derived acetylcholine on airway smooth muscle contraction.
Zaagsma Johan, Gosens Reinoud, Meurs Herman, Halayko Andrew J 2006, 'Muscarinic receptor signaling in the pathophysiology of asthma and COPD', Respiratory Researchhttp://respiratory-research.com/content/7/1/73. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)