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单词 valproic acid
释义

valproic acid in British English

synthetic crystalline compound, used as an anticonvulsive
See full dictionary entry for valproic

valproic acid in British English

(vælˈprəʊɪk)
noun
a synthetic crystalline compound, used as an anticonvulsive to treat seizure disorders. Formula C7H15COOH
Derived forms
valproate (valˈproate)
noun
Word origin
C20: from val(erian) + pro(pyl) + -ic

valproic acid in American English

(vælˈprouɪk)
noun
Pharmacology
a carboxylic acid, C8H16O2, used for its antiepileptic properties in the treatment of various seizures including petit mal
Word origin
[1970–75; val(eric) + pro(pyl) + -ic]This word is first recorded in the period 1970–75. Other words that entered Englishat around the same time include: Heimlich maneuver, good old boy, postmodernism, relational database, salsa-ic is a suffix forming adjectives from other parts of speech, occurring originally inGreek and Latin loanwords (metallic; poetic; archaic; public) and, on this model, used as an adjective-forming suffix with the particular senses“having some characteristics of” (opposed to the simple attributive use of the basenoun) (balletic; sophomoric); “in the style of” (Byronic; Miltonic); “pertaining to a family of peoples or languages” (Finnic; Semitic; Turkic)

Examples of 'valproic acid' in a sentence
valproic acid

These inhibitors include valproic acid and trichostatin.
Martynov AV, Bomko TV, Nosalskaya TN, Lisnyak YuV, Romanova EA, Kabluchko TV, SidorenkoTA, Igumnova NI, Pogorelaya MS, Shcherbak EM, Yukhimenko VI, Farber BS, Farber SB 2016, 'TUBERCULOSIS AS AN INFECTIOUS PATHOLOGY OF IMMUNE SYSTEM', Anali Mečnikìvsʹkogo Institutuhttp://www.imiamn.org.ua/journal/3_2016/PDF/3.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Response rates to first-line treatment were as follows: valproic acid, 46.3%; and valproic acid plus ethosuximide, 90.9%.
C. Martínez-Ferrández, E. Martínez-Salcedo, C. Casas-Fernández, H. Alarcón-Martínez,S. Ibáñez-Micó, R. Domingo-Jiménez 2019, 'Long-term prognosis of childhood absence epilepsy', Neurología (English Edition)http://www.sciencedirect.com/science/article/pii/S2173580818301949. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
She showed marked improvement after starting memantine and valproic acid.
Giuseppe Quaranta, Angelo Giovanni Icro Maremmani, Giulio Perugi 2015, 'Anti-AMPA-Receptor Encephalitis Presenting as a Rapid-Cycling Bipolar Disorder ina Young Woman with Turner Syndrome', Case Reports in Psychiatryhttp://dx.doi.org/10.1155/2015/273192. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Seizures disappeared by combination of valproic acid and levetiracetam.
Ayşegül Gündüz, Burcu Şahinoğlu, Cengiz Yalçınkaya 2008, 'Rotatory Seizures', Türk Nöroloji Dergisihttp://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-19483. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It should also be noted that, during this treatment, valproic acid was not stopped.
Rohit Aiyer, Margaret Seide, Robert G. Stern 2016, 'Valproic Acid Induced Hyperammonemia in a Long Time Treated Patient', Case Reports in Psychiatryhttp://dx.doi.org/10.1155/2016/6242314. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Anticonvulsants include topiramate when patients are obese, valproic acid and lamotrigine.
Alexandre R. Bisdorff 2011, 'Management of vestibular migraine', Therapeutic Advances in Neurological Disordershttps://doi.org/10.1177/1756285611401647. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Abnormalities of liver transaminases and platelets were observed with concomitant valproic acid therapy.
Bláthnaid McCoy, Laura Wang, Maria Zak, Sameer Al‐Mehmadi, Nadia Kabir, Kenda Alhadid,Kyla McDonald, Grace Zhang, Rohit Sharma, Robyn Whitney, Katia Sinopoli, O. CarterSnead III 2018, 'A prospective open‐label trial of a CBD/THC cannabis oil in dravet syndrome', Annals of Clinical and Translational Neurology https://doi.org/10.1002/acn3.621. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Lithium, carbamazepine and valproic acid are the most used mood stabilizers.
Aida Santin, Keila Ceresér, Adriane Rosa 2005, 'Adesão ao tratamento no transtorno bipolar Compliance to treatment in bipolar disorder',Archives of Clinical Psychiatryhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-60832005000700015. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The coadministration of valproic acid did not influence the pharmacokinetics of paclitaxel.
Maria Graziella Catalano, Mariateresa Pugliese, Marco Gallo, Enrico Brignardello,Paola Milla, Fabio Orlandi, Paolo Piero Limone, Emanuela Arvat, Giuseppe Boccuzzi,Alessandro Piovesan 2016, 'Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel forAnaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase II/IIITrial', International Journal of Endocrinologyhttp://dx.doi.org/10.1155/2016/2930414. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
76% (40) of the evaluated patients were prescribed valproic acid off-label.
Mª Teresa Martínez-Lazcano, Sara Esplá-González, Paola Herraiz-Robles, Pilar Hernández-Pérez,Raquel Chillerón-Cuenca, Emilio Pol-Yanguas 2015, 'Use of valproic acid in long stay units of psychiatry', Farmacia Hospitalariahttp://www.aulamedica.es/fh/pdf/8460.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
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更新时间：2025/1/24 13:27:18