单词	downstream
释义	downstream adverb or adjective down·​stream ˈdau̇n-ˈstrēm  1 : in the direction of or nearer to the mouth of a stream floating downstream located two miles downstream 2 : in or toward the latter stages of a usually industrial process or the stages (such as marketing) after manufacture improving profits downstream downstream products 3 biochemistry : toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets. Marcia Barinaga Example Sentences Recent Examples on the Web Biologists plan to use traps in the river to collect the juvenile salmon and truck them downstream of the dam. Ian Jamesstaff Writer, Los Angeles Times, 16 July 2022 That allowed the researchers to compare crashes downstream of an electronic sign during those weeks with the rest of the month, and to look back to crashes on the same stretch of road during the years before the safety campaign started in 2012. Jonathan M. Gitlin, Ars Technica, 21 Apr. 2022 In France, the Loire river is now so low that the government has released water from dams to ensure a high enough water flow to cool four nuclear plants located downstream, Reuters reported. Colin Lodewick, Fortune, 27 Aug. 2022 The child's body was found downstream near Ciudad Juarez, across the border from El Paso, Texas. CBS News, 23 Aug. 2022 The mainstem Colorado in the western end of the Grand Canyon, farther downstream from the dam, also has seen a rebounding chub population. Brandon Loomis, The Arizona Republic, 19 July 2022 Heavner Canoe and Kayak Rental in Milford closed its rental location in the Metropark, and stopped rentals to paddlers headed downstream at its launch near Proud Lake State Recreation Area — its largest chunk of business at that location. Keith Matheny, Detroit Free Press, 4 Aug. 2022 During normal operations, water is released through a set of eight hydropower penstocks that offer dam operators a wide range of flexibility in the amount of water that can be sent downstream. Zak Podmore, The Salt Lake Tribune, 3 Aug. 2022 The total inflow into Lake Powell is expected to be only 5.6 million acre-feet this year, 58% of average, and 7 million acre-feet will be released downstream to Lake Mead. Zak Podmore, The Salt Lake Tribune, 27 June 2022 See More Word History First Known Use 1591, in the meaning defined at sense 1 Kids Definition downstream adverb down·​stream ˈdau̇n-ˈstrēm  : in the direction a stream is flowing paddling downstream Medical Definition downstream adverb or adjective down·​stream ˌdau̇n-ˈstrēm  1 : in the same direction along a molecule of DNA or RNA as that in which transcription and translation take place and toward the end having a hydroxyl group attached to the position labeled 3′ in the terminal nucleotide a nucleotide sequence located downstream from the regulatory gene effects on the expression of downstream genes compare upstream sense 1 2 : toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets. Marcia Barinaga, Science The tyrosine kinase activity of phosphorylated EGFR [epidermal growth factor receptor] in cancer cells results in the phosphorylation of downstream proteins that incite cell proliferation, invasion, metastasis, and inhibition of apoptosis. Jonathan E. Dowell and John D. Minna, The New England Journal of Medicine
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