dystrophin
noun
dys·tro·phin ˈdi-strə-ˌfin 
: a protein that is associated with a transmembrane complex of skeletal muscle cells and that is absent in Duchenne muscular dystrophy and deficient or defective in Becker muscular dystrophy
Example Sentences
Recent Examples on the Web In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said. 
BostonGlobe.com, 17 Dec. 2019 Duchenne is a rare fatal neuromuscular disease caused by mutations in the dystrophin gene that result in a progressive loss of muscle function and weakness, including in the heart and skeleton. BostonGlobe.com, 24 Dec. 2019 The guide RNAs were designed to trigger production of a missing protein called dystrophin. Sara Reardon, Scientific American, 5 Feb. 2020 In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said. BostonGlobe.com, 17 Dec. 2019 In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said. Adam Feuerstein, STAT, 16 Dec. 2019 In a clinical trial, Vyondys 53 produced a small increase in an important muscle protein called dystrophin that children with Duchenne lack. BostonGlobe.com, 24 Dec. 2019 In a clinical trial, Sarepta’s drug produced a small increase in an important muscle protein called dystrophin that is normally missing in children with Duchenne. Damian Garde, STAT, 12 Dec. 2019 Instead, the Wave drug made no dystrophin protein at all, which raises serious questions about the viability of the company’s entire chemistry platform. BostonGlobe.com, 17 Dec. 2019 See More
BostonGlobe.com, 17 Dec. 2019 Duchenne is a rare fatal neuromuscular disease caused by mutations in the dystrophin gene that result in a progressive loss of muscle function and weakness, including in the heart and skeleton. BostonGlobe.com, 24 Dec. 2019 The guide RNAs were designed to trigger production of a missing protein called dystrophin. Sara Reardon, Scientific American, 5 Feb. 2020 In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said. BostonGlobe.com, 17 Dec. 2019 In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said. Adam Feuerstein, STAT, 16 Dec. 2019 In a clinical trial, Vyondys 53 produced a small increase in an important muscle protein called dystrophin that children with Duchenne lack. BostonGlobe.com, 24 Dec. 2019 In a clinical trial, Sarepta’s drug produced a small increase in an important muscle protein called dystrophin that is normally missing in children with Duchenne. Damian Garde, STAT, 12 Dec. 2019 Instead, the Wave drug made no dystrophin protein at all, which raises serious questions about the viability of the company’s entire chemistry platform. BostonGlobe.com, 17 Dec. 2019 See More Word History
Etymology
dystrophy + -in entry 1
Note: Term introduced by Eric P. Hoffman, Robert H. Brown, Jr., and Louis M. Kunkel in "Dystrophin: The protein product of the Duchenne muscular dystrophy locus," Cell, vol. 51, no. 6, December 24, 1987, pp. 919-28.
First Known Use
1987, in the meaning defined above
Medical Definition
dystrophin
noun
dys·tro·phin ˈdis-trə-ˌfin
: a protein of high molecular weight that is associated with a transmembrane glycoprotein complex of skeletal muscle cells and is absent in Duchenne muscular dystrophy and deficient or of abnormal molecular weight in Becker muscular dystrophy
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