单词	deaminase
释义	deaminase noun de·​am·​i·​nase (ˌ)dē-ˈa-mi-ˌnās  -ˌnāz : an enzyme that hydrolyzes amino compounds (such as amino acids) with removal of the amino group Example Sentences Recent Examples on the Web Splitting the enzyme, called a deaminase, into two harmless halves kept it from killing cells. Sharon Begley, STAT, 8 July 2020 Crucially, the mutations that had broken these genes could in principle be fixed with an adenine deaminase that worked on DNA. The Economist, 26 Oct. 2017 The enzyme needed is an adenine deaminase that works on DNA. The Economist, 26 Oct. 2017 Ramus was born with adenosine deaminase deficiency (ADA), a condition also known as bubble boy disease that affects the immune system. Paul A. Smith, Milwaukee Journal Sentinel, 27 Oct. 2017 Creating this second base editor was harder than the first because an equivalent to the cytidine deaminase used by Dr Liu, which would be needed to pull it off, does not exist in nature. The Economist, 26 Oct. 2017 Getting to the point of mutations Base editors borrow from CRISPR's components—guide RNAs (gRNAs) and Cas9 or other nucleases—but don't cut the double helix and instead chemically alter single bases with deaminase enzymes such as TadA and ADAR. Jon Cohen, Science | AAAS, 25 Oct. 2017 See More Word History Etymology de- + amino + -ase First Known Use 1920, in the meaning defined above Medical Definition deaminase noun de·​am·​i·​nase (ˈ)dē-ˈam-ə-ˌnās, -ˌnāz  variants also desaminase (ˈ)des-  : an enzyme that hydrolyzes amino compounds (as amino acids) with removal of the amino group
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