acetylcholinesterase
noun
ace·tyl·cho·lin·es·ter·ase ə-ˌse-tᵊl-ˌkō-lə-ˈne-stə-ˌrās 
-ˌrāz
: an enzyme that occurs chiefly in cholinergic nerve endings and promotes the hydrolysis of acetylcholine : cholinesterase sense 1
Note: Acetylcholinesterase is also found in red blood cells, where its function is unknown.
Example Sentences
Recent Examples on the Web Steroidal alkaloids such as solanine have atropine-like effects on the nervous system inhibiting the enzyme acetylcholinesterase. 
Chris Smith, BGR, 28 July 2022 These drugs, called acetylcholinesterase inhibitors, can help treat neurodegenerative conditions such as Alzheimer’s. Rebecca Sohn, Scientific American, 21 Apr. 2022 Anyone up for a heated debate about acetylcholinesterase inhibitors? Paul Cappiello, The Courier-Journal, 17 Jan. 2020 The medical team sought to boost the pair’s production of acetylcholinesterase, an enzyme that is vital for the brain to communicate with muscles and that can be blocked by nerve agents. William Booth, Washington Post, 29 May 2018 Toxicologists say that the first days after a poisoning are a crucial threshold for survival, as the body struggles to resynthesize an enzyme, acetylcholinesterase, which is inhibited by nerve agents. Ellen Barry, New York Times, 7 July 2018 Nerve agents, which inhibit the enzyme acetylcholinesterase, can cause fatal respiratory paralysis within minutes if the exposure is severe, the paper said. Ellen Barry, New York Times, 29 May 2018 However, a nerve agent stops acetylcholinesterase from doing its job. Simon Cotton, Scientific American, 9 Mar. 2018 See More
Chris Smith, BGR, 28 July 2022 These drugs, called acetylcholinesterase inhibitors, can help treat neurodegenerative conditions such as Alzheimer’s. Rebecca Sohn, Scientific American, 21 Apr. 2022 Anyone up for a heated debate about acetylcholinesterase inhibitors? Paul Cappiello, The Courier-Journal, 17 Jan. 2020 The medical team sought to boost the pair’s production of acetylcholinesterase, an enzyme that is vital for the brain to communicate with muscles and that can be blocked by nerve agents. William Booth, Washington Post, 29 May 2018 Toxicologists say that the first days after a poisoning are a crucial threshold for survival, as the body struggles to resynthesize an enzyme, acetylcholinesterase, which is inhibited by nerve agents. Ellen Barry, New York Times, 7 July 2018 Nerve agents, which inhibit the enzyme acetylcholinesterase, can cause fatal respiratory paralysis within minutes if the exposure is severe, the paper said. Ellen Barry, New York Times, 29 May 2018 However, a nerve agent stops acetylcholinesterase from doing its job. Simon Cotton, Scientific American, 9 Mar. 2018 See More Word History
Etymology
acetyl(choline) + cholinesterase
First Known Use
1937, in the meaning defined above
Medical Definition
acetylcholinesterase
noun
ace·tyl·cho·lin·es·ter·ase -ˌkō-lə-ˈnes-tə-ˌrās, -ˌrāz
: an enzyme that occurs chiefly in cholinergic nerve endings and promotes the hydrolysis of acetylcholine : cholinesterase sense 1
The therapeutic rationale is that inhibition of acetylcholinesterase enhances sympathetic ganglionic neurotransmission and that the effect is maximal when the patient is upright, since sympathetic-nerve traffic is greatest in this position. Roy Freeman, The New England Journal of Medicine
Roy Freeman, The New England Journal of MedicineTacrine is a potent, centrally active, reversible acetylcholinesterase inhibitor that prevents the degradation of endogenously released acetylcholine. Margaret J. Knapp et al., The Journal of the American Medical Association
Margaret J. Knapp et al., The Journal of the American Medical AssociationNote: Acetylcholinesterase is also found in red blood cells where its function there is unknown.