单词	epigenome
释义	epigenome noun epi·​ge·​nome ˌe-pə-ˈjē-ˌnōm  : the complement of chemical compounds that modify the expression and function of the genome Access to the genes is controlled by the epigenome, a layer of millions of proteins and other marks that attach themselves to the genome. Nicholas Wade Working out which genes are switched on or not involves looking at the epigenome, or the chemical "methyl" tags attached to genes. New Scientist Example Sentences Recent Examples on the Web Cells treated with Yamanaka factors, erases marks on the epigenome, losing their identity thus the reversal to the embryonic state (stem cell). Stephen Ibaraki, Forbes, 13 May 2022 Could the team activate telomerase to rejuvenate the epigenome? Margaret Talbot, The New Yorker, 11 Aug. 2021 David had long suspected that the epigenome was central to longevity. Margaret Talbot, The New Yorker, 11 Aug. 2021 David published a great paper in Nature late last year showing that in mice Yamanaka gene therapy can safety reprogram the epigenome of the retina and restore vision in a mouse model of glaucoma. Alex Zhavoronkov, Forbes, 14 June 2021 Penick said the Indian jumping ant colonies used in the study were the same ones that were collected in India almost 20 years ago and were the first epigenome for the species sequenced. NBC News, 14 Apr. 2021 Molecular biologist David Sinclair of Harvard Medical School, who has long been on the hunt for antiaging strategies, has also looked for signs of aging in the epigenome. Kelly Servick, Science | AAAS, 2 Dec. 2020 The Stanford approach utilizes powerful agents known as Yamanaka factors, which reprogram a cell’s epigenome to its time zero, or embryonic state. Nicholas Wade, New York Times, 24 Mar. 2020 Skinner's own research in animals suggests changes to the epigenome, a swirl of biological factors that affect how genes are expressed, can be passed down through multiple generations. Andrew Curry, Science | AAAS, 18 July 2019 See More Word History Etymology epi- + genome, after epigenetic First Known Use 1991, in the meaning defined above
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