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单词 epistasis
释义

epistasis

noun

epis·​ta·​sis i-ˈpi-stə-səs How to pronounce epistasis (audio)
plural epistases i-ˈpi-stə-ˌsēz How to pronounce epistasis (audio)
: suppression of the effect of a gene by a nonallelic gene
epistatic
ˌe-pə-ˈsta-tik How to pronounce epistasis (audio)
adjective

Example Sentences

Recent Examples on the Web An observed trait may be the result of the interaction of changes in two or more genes simultaneously—a phenomenon called epistasis. William A. Haseltine, Forbes, 10 Dec. 2021 Another, though, is that the fates of mutations can be linked — an effect that population geneticists call synergistic, or narrowing, epistasis. Quanta Magazine, 13 July 2017 Most recent newsletter Kondrashov has investigated the implications of synergistic epistasis with theoretical studies. Quanta Magazine, 13 July 2017

Word History

Etymology

epi- + -stasis, after earlier epistatic, by analogy with metastatic : metastatis and like pairs

Note: The term epistatic was introduced, along with hypostatic, by the English biologist William Bateson (1861-1926) in "Facts Limiting the Theory of Heredity" ("Address delivered at the International Zoological Congress, before the Section of Cytology and Heredity, August 23, 1907"), Science, series 2, vol. 26 (July-December, 1907), issue of November 15, 1907, p. 653: "Till lately we spoke of the relations between the gray color of the mouse to the black color in terms of dominance …We can perhaps best express the relation between the gray and the black by the use of metaphor 'higher and lower,' and I therefore suggest the term epistatic as applicable to characters which have to be, as it were, lifted off in order to permit the lower or hypostatic character to appear."

First Known Use

circa 1917, in the meaning defined above

Medical Definition

epistasis

noun

epis·​ta·​sis i-ˈpis-tə-səs How to pronounce epistasis (audio)
plural epistases -ˌsēz How to pronounce epistasis (audio)
1
a
: suppression of a secretion or discharge
b
: a scum on the surface of urine
2
: suppression of the effect of a gene by a nonallelic gene
the role of epistasis in polygenic inheritance
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更新时间:2024/12/23 23:28:35