Canavan disease

noun

Can·a·van disease ˈka-nə-ˌvan- How to pronounce Canavan disease (audio)

variants or less commonly Canavan's disease

ˈka-nə-ˌvanz- How to pronounce Canavan disease (audio)

: a rare, usually fatal, demyelinating disease of infancy that is characterized by spongy degeneration of the brain caused by an enzyme deficiency and that typically affects individuals of eastern European Jewish ancestry

… was diagnosed before he turned 5 months old with Canavan disease—a rare neurological disorder in which genes don't produce the protective myelin in the brain, causing the brain's white matter to degenerate into spongy tissue riddled with microscopic fluid-filled spaces.

Burt Constable

Note: Canavan disease is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

Word History

Etymology

after Myrtelle May Canavan †1953 U.S. pathologist

First Known Use

1965, in the meaning defined above

单词	Canavan disease
释义	Canavan disease noun Can·a·van disease ˈka-nə-ˌvan- variants or less commonly Canavan's disease ˈka-nə-ˌvanz- : a rare, usually fatal, demyelinating disease of infancy that is characterized by spongy degeneration of the brain caused by an enzyme deficiency and that typically affects individuals of eastern European Jewish ancestry … was diagnosed before he turned 5 months old with Canavan disease—a rare neurological disorder in which genes don't produce the protective myelin in the brain, causing the brain's white matter to degenerate into spongy tissue riddled with microscopic fluid-filled spaces. Burt Constable Note: Canavan disease is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome. Word History Etymology after Myrtelle May Canavan †1953 U.S. pathologist First Known Use 1965, in the meaning defined above Medical Definition Canavan disease noun Can·a·van disease ˈkan-ə-ˌvan- variants also Canavan's disease -ˌvanz- : a rare usually fatal demyelinating disease of infancy that is characterized by spongy degeneration of the brain caused by an enzyme deficiency inherited as an autosomal recessive trait and that typically affects individuals of eastern European Jewish ancestry
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Canavan disease

noun

Word History

Medical Definition

noun