adrenoleukodystrophy
noun
ad·re·no·leu·ko·dys·tro·phy ə-ˈdrē-nō-ˌlü-kō-ˈdi-strə-fē 
: a rare demyelinating disease of the central nervous system that is inherited as a sex-linked recessive trait chiefly affecting males in childhood and that is characterized by progressive blindness, deafness, tonic spasms, and mental deterioration —abbreviation ALD
Example Sentences
Recent Examples on the Web Bluebird’s first treatment, eli-cel, helped children with a lethal neurodegenerative disease called cerebral adrenoleukodystrophy live longer by supplying them with a gene that’s crucial for the proper functioning of brain cells. 
Globe Staff, BostonGlobe.com, 19 June 2022 The medicine, eli-cel, is a one-time treatment for cerebral adrenoleukodystrophy, a genetic neurological disorder that affects young boys. Ed Silverman, STAT, 13 June 2022 On Thursday, Bluebird presented data indicating that 92 percent of children with cerebral adrenoleukodystrophy were still alive two years after eli-cel treatment compared to 57 percent of those without treatment. Ryan Cross, BostonGlobe.com, 10 June 2022 For example, Bluebird bio saw a big setback as some safety issues emerged in an ongoing study of a drug to treat cerebral adrenoleukodystrophy back in August. Trefis Team, Forbes, 23 Dec. 2021 At the same time, its stock dropped 25.9% after disclosing new safety issues with an experimental gene therapy under development to treat cerebral adrenoleukodystrophy, a rare genetic condition. Ed Silverman, STAT, 12 Aug. 2021 Bluebird bio also saw a big setback as some safety issues emerged in an ongoing study of a drug to treat cerebral adrenoleukodystrophy back in August. Trefis Team, Forbes, 19 Oct. 2021 At the same time, its stock dropped 25.9% after disclosing new safety issues with an experimental gene therapy under development to treat cerebral adrenoleukodystrophy, a rare genetic condition. Ed Silverman, STAT, 12 Aug. 2021 At the same time, its stock dropped 25.9% after disclosing new safety issues with an experimental gene therapy under development to treat cerebral adrenoleukodystrophy, a rare genetic condition. Ed Silverman, STAT, 12 Aug. 2021 See More
Globe Staff, BostonGlobe.com, 19 June 2022 The medicine, eli-cel, is a one-time treatment for cerebral adrenoleukodystrophy, a genetic neurological disorder that affects young boys. Ed Silverman, STAT, 13 June 2022 On Thursday, Bluebird presented data indicating that 92 percent of children with cerebral adrenoleukodystrophy were still alive two years after eli-cel treatment compared to 57 percent of those without treatment. Ryan Cross, BostonGlobe.com, 10 June 2022 For example, Bluebird bio saw a big setback as some safety issues emerged in an ongoing study of a drug to treat cerebral adrenoleukodystrophy back in August. Trefis Team, Forbes, 23 Dec. 2021 At the same time, its stock dropped 25.9% after disclosing new safety issues with an experimental gene therapy under development to treat cerebral adrenoleukodystrophy, a rare genetic condition. Ed Silverman, STAT, 12 Aug. 2021 Bluebird bio also saw a big setback as some safety issues emerged in an ongoing study of a drug to treat cerebral adrenoleukodystrophy back in August. Trefis Team, Forbes, 19 Oct. 2021 At the same time, its stock dropped 25.9% after disclosing new safety issues with an experimental gene therapy under development to treat cerebral adrenoleukodystrophy, a rare genetic condition. Ed Silverman, STAT, 12 Aug. 2021 At the same time, its stock dropped 25.9% after disclosing new safety issues with an experimental gene therapy under development to treat cerebral adrenoleukodystrophy, a rare genetic condition. Ed Silverman, STAT, 12 Aug. 2021 See More Word History
Etymology
adreno- + leukodystrophy
First Known Use
1973, in the meaning defined above
Medical Definition
adrenoleukodystrophy
noun
adre·no·leu·ko·dys·tro·phy
variants or chiefly British adrenoleucodystrophy
-ˌlü-kō-ˈdis-trə-fē
plural adrenoleukodystrophies
: a rare demyelinating disease of the central nervous system that is inherited as an X-linked recessive trait chiefly affecting males in childhood and that is characterized by progressive blindness, deafness, tonic spasms, and mental deterioration —abbreviation ALD
called also encephalitis periaxialis diffusa, Schilder's disease, Schilder's encephalitis