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单词 oligonucleotide
释义

oligonucleotide

noun

ol·​i·​go·​nu·​cle·​o·​tide ə-ˌli-gə-ˈnü-klē-ə-ˌtīd How to pronounce oligonucleotide (audio)
-ˈnyü-
: a short nucleic-acid chain usually consisting of up to approximately 20 nucleotides

Example Sentences

Recent Examples on the Web The company's encoding starts with a library of dozens to hundreds of short pieces of DNA called oligos (short for oligonucleotide). John Timmer, Ars Technica, 15 Sep. 2022 Yet another approach, with Ionis Pharmaceuticals, involves using antisense oligonucleotides, which are pieces of nucleic acids designed to bind to cells’ RNA — in this case, to fix a problem that leads to the production of abnormal glycogen. Laurie Mcginley, Anchorage Daily News, 5 June 2020 To that end, the researchers turned to something called antisense oligonucleotides. Lydia Denworth, Scientific American, 3 Mar. 2020 The newest oligonucleotide drugs are designed to tackle rare diseases. Lydia Denworth, Scientific American, 3 Mar. 2020 But any chain that is short—usually 15 to 20 nucleotides—is considered an oligonucleotide. Lydia Denworth, Scientific American, 3 Mar. 2020 Targeted lowering of PrP in the brain may now be achievable using antisense oligonucleotides, or ASOs. Scientific American, 29 Feb. 2020 Free oligonucleotides did not cross the cell membrane. Scientific American, 25 Dec. 2019 But one patient advocacy group has publicly shared that Yu’s team has designed an oligonucleotide for a toddler with ataxia-telangiectasia, a neurodegenerative disorder, and hoped to begin to treat her this fall. Jocelyn Kaiser, Science | AAAS, 9 Oct. 2019 See More

Word History

First Known Use

1942, in the meaning defined above

Medical Definition

oligonucleotide

noun

oli·​go·​nu·​cle·​o·​tide -ˈn(y)ü-klē-ə-ˌtīd How to pronounce oligonucleotide (audio)
: a relatively short single-stranded nucleic-acid chain (as an oligodeoxynucleotide or oligoribonucleotide) usually consisting of up to approximately 20 nucleotides
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更新时间:2025/2/3 15:38:48