单词	prion protein
释义	prion protein noun : a glycoprotein found especially on the cell surface of neurons in the brain and spinal cord that sometimes occurs in an abnormal misfolded form which proliferates by inducing the normal protein to convert to the misfolded pathogenic form When the normal prion protein misfolds, it resists recycling and forms a hardy gunk. Some aspect of this process produces lethal sponge-like holes in brain cells. Sandra Blakeslee —abbreviation PrP see prion entry 2 Example Sentences Recent Examples on the Web But these conditions are increasingly being seen as variants of the same disease, all stemming from the misfolding of one specific protein: the prion protein, or PrP. Vallabh and Minikel believe this protein is a suitable target for ASO treatments. Bret Stetka, Scientific American, 15 Aug. 2019 Why these prion proteins change in harmful ways is not yet understood. Korin Miller, SELF, 20 Feb. 2019 Generally, prions are infectious, deformed versions of the normal prion protein (PRNP), which functions on the outside of healthy cells in the brain. Beth Mole, Ars Technica, 26 Apr. 2018 The gnarled versions prompt normal prion proteins to deform and malfunction, setting off a cascade that leads to telltale clumps of contorted proteins. Beth Mole, Ars Technica, 26 Apr. 2018 Word History First Known Use 1982, in the meaning defined above
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