protease

noun

pro·te·ase ˈprō-tē-ˌās How to pronounce protease (audio)

-ˌāz

: any of numerous enzymes that hydrolyze proteins and are classified according to the most prominent functional group (such as serine or cysteine) at the active site

called also proteinase

Example Sentences

Recent Examples on the Web This resistance, in addition to new mutations, is likely related to sensitivity to a membrane protease, TMPRSS2, that is associated with cell membrane infectivity.

William A. Haseltine, Forbes, 11 July 2022 Paxlovid blocks the virus’ enzyme protease, whereas VV116 and remdesivir inhibit the enzyme RNA polymerase.

Mary Hui, Quartz, 6 July 2022 Numerous viruses have difficulty shifting their protease to evade medicinal threats.

Jason Mast, STAT, 29 May 2022 Researchers designed the pill to stop the coronavirus from spreading in people by blocking activity of a key enzyme, known as protease, which the virus needs to replicate.

Joseph Walker, WSJ, 22 Dec. 2021 Allerton’s team had a starting molecule, and began trying to make other molecules that would affect the same protease enzyme.

Matthew Herper, STAT, 28 Apr. 2022 Once assembled, the inflammasome activates a protease called caspase-1.

William A. Haseltine, Forbes, 21 Apr. 2022 Paxlovid is a made up of two protease inhibitors, including one used in treating HIV as a booster medicine.

Patrick Jackson, The Conversation, 28 Apr. 2022 That’s one reason that, from the start, the team planned to combine their medicine with ritonavir, which is commonly used with protease inhibitors to treat HIV to increase blood levels of drug.

Matthew Herper, STAT, 28 Apr. 2022 See More

Word History

Etymology

borrowed from French protéase, from protéine protein + -ase -ase

Note: The French term was probably introduced by the Italian microbiologist and philosopher Giovanni Malfitano (1872-1941) in "Sur le protéase de l'Aspergillus niger," Annales de l'Institut Pasteur, tome quatorzième (1900), p. 420. The term protease was used in English without attribution to Malfitano and perhaps coined independently by the British botanist Sydney Howard Vines (1849-1934) in "Proteolytic Enzymes in Plants," Annals of Botany, vol. 17, no. 65 (January, 1903), p. 237.

First Known Use

1903, in the meaning defined above

单词	protease
释义	protease noun pro·te·ase ˈprō-tē-ˌās -ˌāz : any of numerous enzymes that hydrolyze proteins and are classified according to the most prominent functional group (such as serine or cysteine) at the active site called also proteinase Example Sentences Recent Examples on the Web This resistance, in addition to new mutations, is likely related to sensitivity to a membrane protease, TMPRSS2, that is associated with cell membrane infectivity. William A. Haseltine, Forbes, 11 July 2022 Paxlovid blocks the virus’ enzyme protease, whereas VV116 and remdesivir inhibit the enzyme RNA polymerase. Mary Hui, Quartz, 6 July 2022 Numerous viruses have difficulty shifting their protease to evade medicinal threats. Jason Mast, STAT, 29 May 2022 Researchers designed the pill to stop the coronavirus from spreading in people by blocking activity of a key enzyme, known as protease, which the virus needs to replicate. Joseph Walker, WSJ, 22 Dec. 2021 Allerton’s team had a starting molecule, and began trying to make other molecules that would affect the same protease enzyme. Matthew Herper, STAT, 28 Apr. 2022 Once assembled, the inflammasome activates a protease called caspase-1. William A. Haseltine, Forbes, 21 Apr. 2022 Paxlovid is a made up of two protease inhibitors, including one used in treating HIV as a booster medicine. Patrick Jackson, The Conversation, 28 Apr. 2022 That’s one reason that, from the start, the team planned to combine their medicine with ritonavir, which is commonly used with protease inhibitors to treat HIV to increase blood levels of drug. Matthew Herper, STAT, 28 Apr. 2022 See More Word History Etymology borrowed from French protéase, from protéine protein + -ase -ase Note: The French term was probably introduced by the Italian microbiologist and philosopher Giovanni Malfitano (1872-1941) in "Sur le protéase de l'Aspergillus niger," Annales de l'Institut Pasteur, tome quatorzième (1900), p. 420. The term protease was used in English without attribution to Malfitano and perhaps coined independently by the British botanist Sydney Howard Vines (1849-1934) in "Proteolytic Enzymes in Plants," Annals of Botany, vol. 17, no. 65 (January, 1903), p. 237. First Known Use 1903, in the meaning defined above Phrases Containing protease protease inhibitor protease inhibitor Medical Definition protease noun pro·te·ase ˈprōt-ē-ˌās, -ˌāz : any of numerous enzymes that hydrolyze proteins and are classified according to the most prominent functional group (as serine or cysteine) at the active site called also proteinase compare peptidase
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protease

noun

Example Sentences

Word History

Phrases Containing protease

Medical Definition

noun