单词	SERM
释义	SERM noun ˈsərm  : selective estrogen receptor modulator Word History First Known Use 1994, in the meaning defined above Medical Definition SERM noun ˈsərm  : selective estrogen receptor modulator Dramatic research findings have recently focused new attention on so-called designer estrogens, the medicines known more technically as selective estrogen receptor modulators (SERMs). These agents behave like estrogen in some tissues but block its action in others. V. Craig Jordan, Scientific American The structural features of each SERM differ so that unique ligand-induced conformational changes take place in the ER [estrogen receptor], which are thought to be the likely basis for tissue-selective pharmacology. For example, raloxifene operates as an estrogen agonist in bone but as an antagonist in the breast and uterus. Gideon A. Rodan et al., Science
随便看	loses one's temper loses out loses to loseyite losh loshes losing losing (to) losing ground losing hazard losing heart losing his grip on reality losing it losing one's cool losing one's heart losing one's heart (to) losing one's heart to losing one's lunch losing one's temper losing out losing record losing streak losing to losing/winning record losings

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