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单词 angiotensin
释义

angiotensin

noun

an·​gio·​ten·​sin ˌan-jē-ō-ˈten(t)-sən How to pronounce angiotensin (audio)
: either of two forms of a kinin of which one has marked vasoconstrictive action
also : a synthetic amide derivative of the physiologically active form used to treat some forms of hypotension

Example Sentences

Recent Examples on the Web Quinapril is an angiotensin-converting enzyme (ACE) inhibitor that prevents blood vessels from narrowing, while hydrochlorothiazide is a diuretic, which causes a person to urinate more and flushes out sodium in the body. Sophie Mellor, Fortune, 23 Mar. 2022 The angiotensin-converting enzyme 2 (ACE2) protein, which is present on the surface of many human cells, can be mixed into chewing gum. Abdullah Iqbal, Scientific American, 24 Feb. 2022 Millions of blood-pressure pills known as angiotensin II receptor blockers were recalled beginning in July 2018 after it was found their active ingredients were contaminated with NDMA as a byproduct of the manufacturing process. Anna Edney, Bloomberg.com, 30 May 2020 The ape form of the angiotensin-converting enzyme 2 receptor that the new coronavirus uses to enter cells is identical to the human one, making it likely that apes can be infected, according to an 11 April preprint on bioRxiv. Ann Gibbons, Science | AAAS, 1 May 2020 The spike protein attaches to a receptor on human cells called angiotensin-converting enzyme 2. Kai Kupferschmidt, Science | AAAS, 28 Apr. 2020 Research has shown estrogen may have an effect on a protein known as angiotensin-converting enzyme 2 (ACE2), for example. Roni Caryn Rabin, New York Times, 27 Apr. 2020 Research has shown estrogen may have an effect on a protein known as angiotensin-converting enzyme 2 (ACE2), for example. Roni Caryn Rabin, BostonGlobe.com, 27 Apr. 2020 In a healthy person, the ACE2 receptor chops up two forms of a protein called angiotensin to keep blood pressure stable, among other things. Kate Sheridan, STAT, 10 Apr. 2020 See More

Word History

Etymology

angiotonin, an earlier name for the substance (from angio- + Greek tónos "stretching, strain, tension," alluding to its pressor effect + -in entry 1) + hypertensin, a synonymous name, from hypertens(ion) + -in entry 1, after Spanish hipertensina — more at tone entry 1

Note: The term angiotonin was introduced by the American physiologist Irvine H. Page (1901-91) and biochemist Oscar M. Helmer in "A crystalline pressor substance (angiotonin) resulting from the reaction between renin and renin activator," Journal of Experimental Medicine, vol. 71, No. 1 (January 1, 1940), pp. 29-42. The etymology is stated explicitly: "For this substance we suggest the name 'angiotonin' [Greek ἀγγεῖον, blood vessel, + τόνος (τείνω), strain]" (p. 29). Spanish hipertensina was introduced by the Argentine physiologist Eduardo Braun-Menéndez (1903-59) and coworkers in "La sustancia hipertensora de la sangre del riñón isquemiado," Revista de la Sociedad Argentina de Biología, vol. 15 (1939), pp. 420-25. Page and Braun-Menéndez later agreed to merge the two synonymous names into angiotensin; see "Suggested Revision of Nomenclature—Angiotensin," Science, vol. 127, Issue 3292 (January 31, 1958), p. 242.

First Known Use

1958, in the meaning defined above

Medical Definition

angiotensin

noun

an·​gio·​ten·​sin ˌan-jē-ō-ˈten(t)-sən How to pronounce angiotensin (audio)
1
: either of two forms of a kinin of which one has marked physiological activity and the other is its physiologically inactive precursor
especially : angiotensin ii
2
: a synthetic amide derivative of angiotensin II used to treat some forms of hypotension
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更新时间:2025/2/3 16:35:19