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单词	antimetabolite
释义	antimetabolite noun an·​ti·​me·​tab·​o·​lite ˌan-tē-mə-ˈta-bə-ˌlīt, ˌan-ˌtī-  : a substance that is structurally similar to a metabolite (such as a coenzyme) and that serves to inhibit a particular cellular function (such as DNA synthesis) by interfering with or blocking the metaboliteʼs action From the start [Gertrude] Elion concentrated her research on using purine and pyrimidine antimetabolites to interfere with the synthesis of nucleic acids … Mairin Brennan antimetabolic ˌan-tē-ˌme-tə-ˈbä-lik  ˌan-tī- adjective a drug with antimetabolic action Word History First Known Use 1945, in the meaning defined above Medical Definition antimetabolite noun an·​ti·​me·​tab·​o·​lite ˌant-i-mə-ˈtab-ə-ˌlīt, ˌan-ˌtī-  : a substance that is structurally similar to a metabolite (as a coenzyme) and that serves to inhibit a particular cellular function (as DNA synthesis) by interfering with or blocking the metaboliteʼs action Antimetabolites, such as methotrexate masquerade as essential nutrients, which the cell uses instead of real nutrients and thus dies. Jane E. Brody antimetabolite therapy
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