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单词	cyclosporine
释义	cyclosporine noun cy·​clo·​spor·​ine ˌsī-klə-ˈspȯr-ən  -ˌēn variants or less commonly cyclosporin ˌsī-klə-ˈspȯr-ən  : an immunosuppressive drug C62H111N11O12 that is a cyclic polypeptide obtained as a metabolite from a fungus (Beauveria nivea synonym Tolypocladium inflatum) and is used especially to prevent rejection of transplanted organs and in the treatment of rheumatoid arthritis and psoriasis Example Sentences Recent Examples on the Web Kahwash sent the patient to the lab to get tested for each of them and started her on a higher dose of cyclosporine. New York Times, 9 May 2022 One example of an immunosuppressant used to help manage atopic dermatitis is the oral medication cyclosporine, says Dr. Libby. Jessie Van Amburg, Health.com, 30 Nov. 2021 These drops are called cyclosporine (Restasis) and lifitegrast (Xiidra). Jenny Mccoy, Health.com, 16 Nov. 2021 One of the tale’s greatest heroes is the drug cyclosporine, approved in 1983 for use in transplants. Star Tribune, 21 Aug. 2020 For more widespread disease, systemic therapy is generally required, which can involve either oral medication (like methotrexate, acitretin, or cyclosporine) or injectable biologic medications (like Enbrel, Humira or Stelara). Lambeth Hochwald, Health.com, 29 Aug. 2019 Isolated from a soil fungus found in Africa, cyclosporine was synthesized as an immunosuppressant by the pharmaceutical company Sandoz in 1980, and after wide testing was released into the market in 1983. oregonlive, 5 Oct. 2019 Systemic therapies for psoriasis include oral therapy (such as methotrexate, cyclosporine, oral retinoids, and apremilast) as well as numerous injectable biologic and biosimilar medications. Jenna Birch, SELF, 28 Oct. 2019 Are or may be pregnant, have osteoporosis, have severe liver disease, or take medicines known as strong OATP1B1 inhibitors, such as cyclosporine or gemfibrozil. Vogue, 23 Aug. 2019 See More Word History Etymology International Scientific Vocabulary cycl- + spor- + -ine entry 2 First Known Use 1976, in the meaning defined above Medical Definition cyclosporine noun cy·​clo·​spor·​ine ˌsī-klə-ˈspȯr-ᵊn, -ˌēn  variants also cyclosporin ˌsī-klə-ˈspȯr-ᵊn or cyclosporine A or cyclosporin A or chiefly British ciclosporin or ciclosporin A : a cyclosporin C62H111N11O12 that is an immunosuppressive cyclic polypeptide obtained as a metabolite from a fungus (Beauveria nivea synonym Tolypocladium inflatum) and is used especially to prevent rejection of transplanted organs and in the treatment of rheumatoid arthritis and psoriasis The indications for treatment with cyclosporine are rapidly expanding. Once used only for the prevention of organ transplant rejection, cyclosporine is now approved for psoriasis and rheumatoid arthritis and is being prescribed for conditions ranging from autoimmune diseases to atopic dermatitis. Mark Lebwohl, Scientitic American Medicine Bulletin Recently, cyclosporine has come on the market as an especially useful immunosuppressive agent, since it offers essentially equal protection from rejection of the transplant, while causing less impairment of immunological defenses against bacteria and viruses. James D. Hardy, The World of Surgery Cyclosporin, an antirejection drug that helps make organ transplants feasible, comes from a Norwegian fungus. Jon R. Luoma, Audubon Prolonged treatment with glucocorticoids can have undesirable side effects (including diabetes mellitus), while cyclosporine A can cause diarrhea and vomiting (and diminished bank accounts for owners of large dogs). Dog Watch Note: Trademarks for cyclosporine include Neoral, Restasis, and Sandimmune.
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