单词	misfold
释义	misfold verb mis·​fold ˌmis-ˈfōld  misfolded; misfolding; misfolds intransitive verb of a protein : to fold into an incorrect three-dimensional shape that is typically nonfunctional and often resistant to breakdown Prions force proteins to misfold throughout the nervous system and bone marrow, eventually ravaging the brain and crippling the afflicted cow. Cathy Booth Thomas misfolded ˌmis-ˈfōl-dəd  adjective Scientists have identified a handful of diseases caused by misfolded proteins called prions … Nathan Seppa Example Sentences Recent Examples on the Web Working together, Orr and Zoghbi found that repeat expansions make proteins misfold and clump together in cerebellar neurons, eventually leading to death. Elizabeth Cooney, STAT, 3 June 2022 Some of the structures made possible by a larger alphabet might be of poor quality, with a greater risk of misfolding, Ellington said. Quanta Magazine, 10 July 2015 Creutzfeldt–Jakob disease is a rare brain disorder caused by misfolding brain proteins called prions. Avery Thompson, Popular Mechanics, 17 Oct. 2018 The scientists used a technique called protein misfolding cyclic amplification (PMCA) to test for the presence of CWD prions in soil and water taken from mineral licks in south-central Wisconsin. Paul A. Smith, Milwaukee Journal Sentinel, 2 May 2018 Sometime in the next year, Gandy’s team hopes to have the tau-positive patients from its imaging study participate in a small clinical trial of a new medication that has shown the ability to repair and clear out misfolded tau in animals. Patrick Hruby, The Atlantic, 21 Sep. 2017 But prions are misfolded in sections, taking on a flat shape rather than the normal spiraling pattern. Mark Johnson, Milwaukee Journal Sentinel, 6 July 2017 In which book was a puffy, misfolded map found on a workbench? Andrea Mills, Orange County Register, 8 Mar. 2017 See More Word History First Known Use 1971, in the meaning defined above Medical Definition misfold intransitive verb mis·​fold ˌmis-ˈfōld  misfolded; misfolding of a protein : to fold into an incorrect three-dimensional shape that is typically nonfunctional and often resistant to breakdown The abnormal prions induce normal prion proteins to misfold, and eventually the brain develops spongelike holes. Bette Hileman
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